Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy
Today's challenge for precision medicine involves the integration of the impact of molecular
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
clocks on drug pharmacokinetics, toxicity, and efficacy toward personalized chronotherapy …
Systems chronotherapeutics
Chronotherapeutics aim at treating illnesses according to the endogenous biologic rhythms,
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
which moderate xenobiotic metabolism and cellular drug response. The molecular clocks …
Human circadian phase–response curves for exercise
SD Youngstedt, JA Elliott… - The Journal of physiology, 2019 - Wiley Online Library
Key points Exercise elicits circadian phase‐shifting effects, but additional information is
needed. The phase–response curve describing the magnitude and direction of circadian …
needed. The phase–response curve describing the magnitude and direction of circadian …
[HTML][HTML] The genomic landscape and pharmacogenomic interactions of clock genes in cancer chronotherapy
Cancer chronotherapy, treatment at specific times during circadian rhythms, endeavors to
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …
optimize anti-tumor effects and to lower toxicity. However, comprehensive characterization of …
Dosing-time makes the poison: circadian regulation and pharmacotherapy
R Dallmann, A Okyar, F Lévi - Trends in molecular medicine, 2016 - cell.com
Daily rhythms in physiology significantly modulate drug pharmacokinetics and
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
pharmacodynamics according to the time-of-day, a finding that has led to the concept of …
The circadian clock in cancer development and therapy
L Fu, NM Kettner - Progress in molecular biology and translational …, 2013 - Elsevier
Most aspects of mammalian function display circadian rhythms driven by an endogenous
clock. The circadian clock is operated by genes and comprises a central clock in the brain …
clock. The circadian clock is operated by genes and comprises a central clock in the brain …
Chronopharmacology: new insights and therapeutic implications
Most facets of mammalian physiology and behavior vary according to time of day, thanks to
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …
endogenous circadian clocks. Therefore, it is not surprising that many aspects of …
The circadian timing system in clinical oncology
The circadian timing system (CTS) controls several critical molecular pathways for cancer
processes and treatment effects over the 24 hours, including drug metabolism, cell cycle …
processes and treatment effects over the 24 hours, including drug metabolism, cell cycle …
Recommendations for high-priority research on cancer-related fatigue in children and adults
Over the past decades, some scientific progress has been made in understanding and
treating cancer-related fatigue (CRF). However, three major problems have limited further …
treating cancer-related fatigue (CRF). However, three major problems have limited further …
The circadian clock as a potential biomarker and therapeutic target in pancreatic cancer
Pancreatic cancer (PC) has a very high mortality rate globally. Despite ongoing efforts, its
prognosis has not improved significantly over the last two decades. Thus, further …
prognosis has not improved significantly over the last two decades. Thus, further …