Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

The regulated transcription of genes determines cell identity and function. Recent structural
studies have elucidated mechanisms that govern the regulation of transcription by RNA …

While long non-coding RNA (lncRNA) genes have attracted a lot of attention in the last
decade, the focus regarding their mechanisms of action has been primarily on the RNA …

Exercise is fundamental for good health, whereas physical inactivity underpins many chronic
diseases of modern society. It is well appreciated that regular exercise improves metabolism …

Genome packaging by nucleosomes is a hallmark of eukaryotes. Histones and the pathways
that deposit, remove, and read histone modifications are deeply conserved. Yet, we lack …

Nucleosomes wrap DNA and impede access for the machinery of transcription. The core
histones that constitute nucleosomes are subject to a diversity of posttranslational …

Nuclear receptor-binding SET-domain protein 1 (NSD1), a methyltransferase that catalyzes
H3K36me2, is essential for mammalian development and is frequently dysregulated in …

Histones and associated chromatin proteins have essential functions in eukaryotic genome
organization and regulation. Despite this fundamental role in eukaryotic cell biology, we lack …

The organization of genomic DNA into defined nucleosomes has long been viewed as a
hallmark of eukaryotes. This paradigm has been challenged by the identification of" …

Cytosine DNA methylation (5mC) is a widespread base modification in eukaryotic genomes
with critical roles in transcriptional regulation. In recent years, our understanding of 5mC has …