Azacytidine was first synthesized almost 40 years ago. It was demonstrated to have a wide
range of anti-metabolic activities when tested against cultured cancer cells and to be an …

The term epigenetics refers to stable patterns of gene expression that are seen during
differentiation or X chromosome inactivation and are not dependent on dynamic changes in …

In Biocultural Creatures, Samantha Frost brings feminist and political theory together with
findings in the life sciences to recuperate the category of the human for politics. Challenging …

Densely methylated DNA associates with transcriptionally repressive chromatin
characterized by the presence of underacetylated histones 1, 2. Recently, these two …

Neoplastic cells simultaneously harbor widespread genomic hypomethylation, more
regional areas of hypermethylation, and increased DNA-methyltransferase (DNA-MTase) …

Genomic imprinting is regulated by differential methylation of the paternal and maternal
genome. However, it remains unknown how parental imprinting is established during …

Background: Hereditary pancreatitis is an autosomal-dominant disease, with a variable
expression and an estimated penetrance of 80%. The gene for this disease has recently …

Studies of animal culture have not normally included a consideration of cetaceans.
However, with several long-term field studies now maturing, this situation should change …

We describe a gene encoding p73, a protein that shares considerable homology with the
tumor suppressor p53. p73 maps to 1p36, a region frequently deleted in neuroblastoma and …

Genomic imprinting is an epigenetic phenomenon leading to parentally biased gene
expression. Throughout the years, extensive efforts have been made to characterize the …