Abstract Introduction Recently, Nrf2/HO-1 has received extensive attention as the main
regulatory pathway of intracellular defense against oxidative stress and is considered an …

Cells of the vascular wall are exquisitely sensitive to changes in their mechanical
environment. In healthy vessels, mechanical forces regulate signaling and gene expression …

Endothelial cells (ECs) lining all blood vessels are subjected to large mechanical stresses
that regulate their structure and function in health and disease. Here, we review EC …

NADPH oxidases (NOX) are enzyme complexes that have received much attention as key
molecules in the development of vascular dysfunction. NOX have the primary function of …

Two prominent concepts for the sensing of shear stress by endothelium are the PIEZO1
channel as a mediator of mechanically activated calcium ion entry and the PECAM1 cell …

Mechanical forces are fundamental in cardiovascular biology, and deciphering the
mechanisms by which they act remains a testing frontier in cardiovascular research. Here …

The glycocalyx is a polysaccharide structure that protrudes from the body of a cell. It is
primarily conformed of glycoproteins and proteoglycans, which provide communication …

Piezo1 is a mechanosensitive ion channel with essential roles in cardiovascular, lung,
urinary, and immune functions. Piezo1 is widely distributed in different tissues in the human …

Atherosclerosis is a chronic progressive inflammatory process that can eventually lead to
cardiovascular disease (CVD). Despite available treatment, the prevalence of …

Chronic obstructive pulmonary disease (COPD) and atherosclerosis are chronic irreversible
diseases, that share a number of common causative factors including cigarette smoking …