How DNA methylation is interpreted and influences genome regulation remains largely
unknown. Proteins of the methyl-CpG-binding domain (MBD) family are primary candidates …

Cancer is the second leading cause of death in US. Despite the emergence of new, targeted
agents, and the use of various therapeutic combinations, none of the available treatment …

Cancer-associated DNA hypomethylation is as prevalent as cancer-linked hypermethylation,
but these two types of epigenetic abnormalities usually seem to affect different DNA …

DNA methylation regulates many cellular processes, including embryonic development,
transcription, chromatin structure, X-chromosome inactivation, genomic imprinting and …

Hepatocarcinogenesis is a slow process during which genomic changes progressively alter
the hepatocellular phenotype to produce cellular intermediates that evolve into …

Hepatocellular carcinoma (HCC) is a deadly tumour whose causative agents are generally
well known, but whose pathogenesis remains poorly understood. Nevertheless, key genetic …

The hepatitis B virus (HBV) X protein has been implicated as a potential trigger of the
epigenetic modifications of some genes during hepatocarcinogenesis, but the underlying …

Purpose: Tumor-infiltrating lymphocytes represent the host immune response to cancer.
CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) suppress the immune reaction. The aim of …

Hepatocellular carcinoma (HCC) is one of most lethal cancers worldwide. Strategic
decisions for the advancement of molecular therapies in this neoplasm require a clear …

Hepatocellular carcinoma (HCC) is the fifth most common cancer worldwide, accounting for
an estimated 600,000 deaths annually. Aberrant methylation, consisting of DNA …