RORγt, the master transcription factor for cytokine interleukin (IL)-17, is expressed explicitly
in Th17 cells, γδT cells, and type 3 innate lymphoid cells in mice and humans. Since …

The ever-increasing prevalence of noncommunicable diseases (NCDs) represents a major
public health burden worldwide. The most common form of NCD is metabolic diseases …

Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function
regulation, play important roles in regulating a variety of cellular physiological and …

Glioblastoma (GBM) is the most common primary brain tumor in adults, and the most lethal
form of glioma, characterized by variable histopathology, aggressiveness and poor clinical …

Interferon regulatory factor (IRF) 7 was originally identified as master transcriptional factor
that produced IFN-I and regulated innate immune response, subsequent studies have …

Post-translational modification (PTM) is an essential mechanism for enhancing the
functional diversity of proteins and adjusting their signaling networks. The reversible …

Angiogenesis contributes fundamentally to embryonic development, tissue homeostasis,
and wound healing. Basic fibroblast growth factor (FGF2) is recognized as the first …

Targeted protein degradation and stabilization are promising therapeutic modalities
because of their potency, versatility and their potential to expand the druggable target …

Intracellular degradation of proteins and organelles by the autophagy-lysosome system is
essential for cellular quality control and energy homeostasis. Besides degradation …

Simple Summary The small ubiquitin-like modifier (SUMO) pathway regulates the hallmark
properties of cancer cells. Moreover, alterations in activity and in levels of SUMO machinery …