Lung cancer is the leading cause of cancer-related mortality worldwide. Advances in our
understanding of the genomics of lung cancer have led to substantial progress in the …

Patterns of DNA methylation and chromatin structure are profoundly altered in neoplasia
and include genome-wide losses of, and regional gains in, DNA methylation. The recent …

In der WHO-Klassifikation 2020 steht die Unterscheidung von HPV-assoziierten und HPV-
unabhängigen Plattenepithelkarzinomen des unteren weiblichen Genitales im Vordergrund …

We sought to classify endocervical adenocarcinomas (ECAs) based on morphologic
features linked to etiology (ie, human papillomavirus [HPV] infection), unlike the World …

This article reviews the mechanisms of gene silencing in cancer and clinical applications of
this phenomenon. The silencing of genes, especially tumor-suppressor genes, is a key …

The past few years have seen an explosion of interest in the epigenetics of cancer. This has
been a consequence of both the exciting coalescence of the chromatin and DNA …

We are in an era where the potential exists for deriving comprehensive profiles of DNA
alterations characterizing each form of human cancer. Such profiles would provide …

Chromatin alterations have been associated with all stages of tumour formation and
progression. The best characterized are epigenetically mediated transcriptional-silencing …

We have come a long way since the first reports of the existence of aberrant DNA
methylation in human cancer. Hypermethylation of CpG islands located in the promoter …

Recently, the concept that epigenetic, as well as genetic, events might be central to the
evolution of human cancer is re-emerging. Cancers often exhibit an aberrant methylation of …