In response to muscle injury, muscle stem cells integrate environmental cues in the
damaged tissue to mediate regeneration. These environmental cues are tightly regulated to …

Thiazolidinediones (TZDs) are synthetic ligands of Peroxisome-Proliferator-Activated
Receptor gamma (PPAR). Troglitazone, rosiglitazone, and pioglitazone have been …

Background: Sensitizing effects of poly-ADP-ribose polymerase inhibitors have been studied
in several preclinical models, but a clear understanding of predictive biomarkers is lacking …

Human neural stem cell cultures provide progenitor cells that are potential cells of origin for
brain cancers. However, the extent to which genetic predisposition to tumor formation can be …

Neural crest cells (NCC) are stem cells that generate different lineages, including
neuroendocrine, melanocytic, cartilage and bone. The differentiation potential of NCC varies …

The available evidence suggests that the lethality of glioblastoma is driven by small
subpopulations of cells that self-renew and exhibit tumorigenicity. It remains unclear whether …

To investigate long-term trends of animal use, the EU animal use statistics from the 15
countries that have been in the EU since 1995 plus respective data from Switzerland were …

Epigenetic reprogramming is a cancer hallmark, but how it unfolds during early neoplastic
events and its role in carcinogenesis and cancer progression is not fully understood. Here …

Neurological disorders affecting individuals in infancy to old age elude interventions for
meaningful protection against neurodegeneration, and preclinical work has not translated to …

Pluripotent stem cells offer unique avenues to study human-specific aspects of disease and
are a highly versatile tool in cancer research. Oncogenic processes and developmental …