With the exception of a few monogenic forms, Alzheimer disease (AD) has a complex
aetiology that is likely to involve multiple susceptibility genes and environmental factors. The …

Addictions are heritable and unfold dynamically across the lifespan. One prominent
neurobiological theory proposes that substance-induced changes in neural circuitry promote …

Studies of DNA methylation (DNAm) in solid human tissues are relatively scarce; tissue-
specific characterization of DNAm is needed to understand its role in gene regulation and its …

Background Oxidative stress (OS) is a key pathophysiological mechanism in Crohn's
disease (CD). OS-related genes can be affected by environmental factors, intestinal …

Alcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders
with etiological origins in the brain and the environment. To outline the causes and …

Sulfotransferases (SULTs) are Phase II drug-metabolizing enzymes (DMEs) catalyzing the
sulfation of a variety of endogenous compounds, natural products, and drugs. Various drugs …

Alcohol use disorder is associated with systemic inflammation and organ dysfunction
especially in the liver and the brain. For more than a decade, studies have highlighted …

Genome-wide association studies (GWASs) have identified over 140 colorectal cancer
(CRC)-associated loci; however, target genes at the majority of loci and underlying …

Background Considered as the representatives of neurodegenerative diseases, Alzheimer's
disease (AD) and glaucoma are complex progressive neuropathies affected by both genetic …

Genome-wide association studies (GWAS) in admixed populations such as African
Americans (AA) have limited sample sizes, resulting in poor performance of polygenic risk …