Pathogenesis and management of abdominal aortic aneurysm

J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …

Development of pharmacotherapies for abdominal aortic aneurysms

LM Weaver, CD Loftin, CG Zhan - Biomedicine & Pharmacotherapy, 2022 - Elsevier
The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …

Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans …

Y Lu, Y Sun, K Xu, F Saaoud, Y Shao… - Frontiers in …, 2022 - frontiersin.org
To determine whether aorta becomes immune organ in pathologies, we performed
transcriptomic analyses of six types of secretomic genes (SGs) in aorta and vascular cells …

Molecular imaging of aortic aneurysm and its translational power for clinical risk assessment

V Rastogi, SJM Stefens, J Houwaart… - Frontiers in …, 2022 - frontiersin.org
Aortic aneurysms (AAs) are dilations of the aorta, that are often fatal upon rupture.
Diagnostic radiological techniques such as ultrasound (US), magnetic resonance imaging …

Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm

MU Wagenhäuser, J Mulorz, KJ Krott… - Cardiovascular …, 2024 - academic.oup.com
Aims Abdominal aortic aneurysm (AAA) is a highly lethal disease with progressive dilatation
of the abdominal aorta accompanied by degradation and remodelling of the vessel wall due …

Apolipoprotein E (ApoE) rescues the contractile smooth muscle cell phenotype in popliteal artery aneurysm disease

J Pauli, T Reisenauer, G Winski, N Sachs… - Biomolecules, 2023 - mdpi.com
Popliteal artery aneurysm (PAA) is the most frequent peripheral aneurysm, primarily seen in
male smokers with a prevalence below 1%. This exploratory study aims to shed light on …

Small AAAs: recommendations for rodent model research for the identification of novel therapeutics

J Golledge, HS Lu, JA Curci - Arteriosclerosis, Thrombosis, and …, 2024 - ahajournals.org
Clinical problem: Most abdominal aortic aneurysms (AAAs) are small with low rupture risk (<
1%/y) when diagnosed but slowly expand to≥ 55 mm and undergo surgical repair. Patients …

Single-Cell RNA sequencing investigation of female-male differences under PAD conditions

G Sánchez Marrero, N Villa-Roel, F Li… - Frontiers in …, 2023 - frontiersin.org
Peripheral arterial disease (PAD) is an age-related medical condition affecting mostly
muscular arteries of the limb. It is the 3rd leading cause of atherosclerotic morbidity. The …

Reducing abdominal aortic aneurysm progression by blocking neutrophil extracellular traps depends on thrombus formation

N Ibrahim, S Bleichert, J Klopf, G Kurzreiter… - Basic to Translational …, 2024 - jacc.org
Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of abdominal aortic
aneurysm (AAA), located in adventitia and intraluminal thrombus. We compared the …

[HTML][HTML] CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development

Y Wang, X Liu, Q Xu, W Xu, X Zhou, A Leask, Z Lin - JCI insight, 2023 - ncbi.nlm.nih.gov
Vascular smooth muscle cell (SMC) phenotypic switching is widely recognized as a key
mechanism responsible for the pathogenesis of several aortic diseases, such as aortic …