Pathogenesis and management of abdominal aortic aneurysm
J Golledge, S Thanigaimani, JT Powell… - European Heart …, 2023 - academic.oup.com
Abdominal aortic aneurysm (AAA) causes∼ 170 000 deaths annually worldwide. Most
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …
guidelines recommend asymptomatic small AAAs (30 to< 50 mm in women; 30 to< 55 mm in …
Development of pharmacotherapies for abdominal aortic aneurysms
The cardiovascular field is still searching for a treatment for abdominal aortic aneurysms
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …
(AAA). This inflammatory disease often goes undiagnosed until a late stage and associated …
Aorta in Pathologies May Function as an Immune Organ by Upregulating Secretomes for Immune and Vascular Cell Activation, Differentiation and Trans …
To determine whether aorta becomes immune organ in pathologies, we performed
transcriptomic analyses of six types of secretomic genes (SGs) in aorta and vascular cells …
transcriptomic analyses of six types of secretomic genes (SGs) in aorta and vascular cells …
Molecular imaging of aortic aneurysm and its translational power for clinical risk assessment
V Rastogi, SJM Stefens, J Houwaart… - Frontiers in …, 2022 - frontiersin.org
Aortic aneurysms (AAs) are dilations of the aorta, that are often fatal upon rupture.
Diagnostic radiological techniques such as ultrasound (US), magnetic resonance imaging …
Diagnostic radiological techniques such as ultrasound (US), magnetic resonance imaging …
Crosstalk of platelets with macrophages and fibroblasts aggravates inflammation, aortic wall stiffening, and osteopontin release in abdominal aortic aneurysm
MU Wagenhäuser, J Mulorz, KJ Krott… - Cardiovascular …, 2024 - academic.oup.com
Aims Abdominal aortic aneurysm (AAA) is a highly lethal disease with progressive dilatation
of the abdominal aorta accompanied by degradation and remodelling of the vessel wall due …
of the abdominal aorta accompanied by degradation and remodelling of the vessel wall due …
Apolipoprotein E (ApoE) rescues the contractile smooth muscle cell phenotype in popliteal artery aneurysm disease
J Pauli, T Reisenauer, G Winski, N Sachs… - Biomolecules, 2023 - mdpi.com
Popliteal artery aneurysm (PAA) is the most frequent peripheral aneurysm, primarily seen in
male smokers with a prevalence below 1%. This exploratory study aims to shed light on …
male smokers with a prevalence below 1%. This exploratory study aims to shed light on …
Small AAAs: recommendations for rodent model research for the identification of novel therapeutics
Clinical problem: Most abdominal aortic aneurysms (AAAs) are small with low rupture risk (<
1%/y) when diagnosed but slowly expand to≥ 55 mm and undergo surgical repair. Patients …
1%/y) when diagnosed but slowly expand to≥ 55 mm and undergo surgical repair. Patients …
Single-Cell RNA sequencing investigation of female-male differences under PAD conditions
G Sánchez Marrero, N Villa-Roel, F Li… - Frontiers in …, 2023 - frontiersin.org
Peripheral arterial disease (PAD) is an age-related medical condition affecting mostly
muscular arteries of the limb. It is the 3rd leading cause of atherosclerotic morbidity. The …
muscular arteries of the limb. It is the 3rd leading cause of atherosclerotic morbidity. The …
Reducing abdominal aortic aneurysm progression by blocking neutrophil extracellular traps depends on thrombus formation
N Ibrahim, S Bleichert, J Klopf, G Kurzreiter… - Basic to Translational …, 2024 - jacc.org
Neutrophil extracellular traps (NETs) are implicated in the pathogenesis of abdominal aortic
aneurysm (AAA), located in adventitia and intraluminal thrombus. We compared the …
aneurysm (AAA), located in adventitia and intraluminal thrombus. We compared the …
[HTML][HTML] CCN2 deficiency in smooth muscle cells triggers cell reprogramming and aggravates aneurysm development
Vascular smooth muscle cell (SMC) phenotypic switching is widely recognized as a key
mechanism responsible for the pathogenesis of several aortic diseases, such as aortic …
mechanism responsible for the pathogenesis of several aortic diseases, such as aortic …