Principles and challenges of genome-wide DNA methylation analysis
PW Laird - Nature Reviews Genetics, 2010 - nature.com
Methylation of cytosine bases in DNA provides a layer of epigenetic control in many
eukaryotes that has important implications for normal biology and disease. Therefore …
eukaryotes that has important implications for normal biology and disease. Therefore …
Analysing and interpreting DNA methylation data
C Bock - Nature Reviews Genetics, 2012 - nature.com
DNA methylation is an epigenetic mark that has suspected regulatory roles in a broad range
of biological processes and diseases. The technology is now available for studying DNA …
of biological processes and diseases. The technology is now available for studying DNA …
Dual functions of Tet1 in transcriptional regulation in mouse embryonic stem cells
Epigenetic modification of the mammalian genome by DNA methylation (5-methylcytosine)
has a profound impact on chromatin structure, gene expression and maintenance of cellular …
has a profound impact on chromatin structure, gene expression and maintenance of cellular …
Genome-wide analysis of 5-hydroxymethylcytosine distribution reveals its dual function in transcriptional regulation in mouse embryonic stem cells
Recent studies have demonstrated that the Ten-eleven translocation (Tet) family proteins
can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) …
can enzymatically convert 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) …
Quantitative comparison of genome-wide DNA methylation mapping technologies
DNA methylation plays a key role in regulating eukaryotic gene expression. Although
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …
mitotically heritable and stable over time, patterns of DNA methylation frequently change in …
[HTML][HTML] A comparative overview of epigenomic profiling methods
In the past decade, assays that profile different aspects of the epigenome have grown
exponentially in number and variation. However, standard guidelines for researchers to …
exponentially in number and variation. However, standard guidelines for researchers to …
Functional DNA methylation differences between tissues, cell types, and across individuals discovered using the M&M algorithm
DNA methylation plays key roles in diverse biological processes such as X chromosome
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
inactivation, transposable element repression, genomic imprinting, and tissue-specific gene …
Comparison of methyl-DNA immunoprecipitation (MeDIP) and methyl-CpG binding domain (MBD) protein capture for genome-wide DNA methylation analysis reveal …
DNA methylation primarily occurs at CpG dinucleotides in mammals and is a common
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …
epigenetic mark that plays a critical role in the regulation of gene expression. Profiling DNA …
Detecting neuroendocrine prostate cancer through tissue-informed cell-free DNA methylation analysis
Purpose: Neuroendocrine prostate cancer (NEPC) is a resistance phenotype that emerges
in men with metastatic castration-resistant prostate adenocarcinoma (CR-PRAD) and has …
in men with metastatic castration-resistant prostate adenocarcinoma (CR-PRAD) and has …
Whole genome DNA methylation analysis based on high throughput sequencing technology
N Li, M Ye, Y Li, Z Yan, LM Butcher, J Sun, X Han… - Methods, 2010 - Elsevier
There are numerous approaches to decipher a whole genome DNA methylation profile
(“methylome”), each varying in cost, throughput and resolution. The gold standard of these …
(“methylome”), each varying in cost, throughput and resolution. The gold standard of these …