Detecting neuroendocrine prostate cancer through tissue-informed cell-free DNA methylation analysis
Purpose: Neuroendocrine prostate cancer (NEPC) is a resistance phenotype that emerges
in men with metastatic castration-resistant prostate adenocarcinoma (CR-PRAD) and has …
in men with metastatic castration-resistant prostate adenocarcinoma (CR-PRAD) and has …
[HTML][HTML] Genome-wide analysis of aberrant methylation in human breast cancer cells using methyl-DNA immunoprecipitation combined with high-throughput …
Y Ruike, Y Imanaka, F Sato, K Shimizu, G Tsujimoto - BMC genomics, 2010 - Springer
Background Cancer cells undergo massive alterations to their DNA methylation patterns that
result in aberrant gene expression and malignant phenotypes. However, the mechanisms …
result in aberrant gene expression and malignant phenotypes. However, the mechanisms …
Genome-wide screen of promoter methylation identifies novel markers in melanoma
Y Koga, M Pelizzola, E Cheng, M Krauthammer… - Genome …, 2009 - genome.cshlp.org
DNA methylation is an important component of epigenetic modifications, which influences
the transcriptional machinery aberrant in many human diseases. In this study we present the …
the transcriptional machinery aberrant in many human diseases. In this study we present the …
Computational analysis of genome-wide DNA methylation during the differentiation of human embryonic stem cells along the endodermal lineage
L Chavez, J Jozefczuk, C Grimm, J Dietrich… - Genome …, 2010 - genome.cshlp.org
The generation of genome-wide data derived from methylated DNA immunoprecipitation
followed by sequencing (MeDIP-seq) has become a major tool for epigenetic studies in …
followed by sequencing (MeDIP-seq) has become a major tool for epigenetic studies in …
[HTML][HTML] Statistical methods for detecting differentially methylated loci and regions
DNA methylation, the reversible addition of methyl groups at CpG dinucleotides, represents
an important regulatory layer associated with gene expression. Changed methylation status …
an important regulatory layer associated with gene expression. Changed methylation status …
Genome-scale DNA methylation analysis
SD Fouse, RP Nagarajan, JF Costello - Epigenomics, 2010 - Taylor & Francis
The haploid human genome contains approximately 29 million CpGs that exist in a
methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA …
methylated, hydroxymethylated or unmethylated state, collectively referred to as the DNA …
Repitools: an R package for the analysis of enrichment-based epigenomic data
Epigenetics, the study of heritable somatic phenotypic changes not related to DNA
sequence, has emerged as a critical component of the landscape of gene regulation. The …
sequence, has emerged as a critical component of the landscape of gene regulation. The …
Combining MeDIP-seq and MRE-seq to investigate genome-wide CpG methylation
DNA CpG methylation is a widespread epigenetic mark in high eukaryotes including
mammals. DNA methylation plays key roles in diverse biological processes such as X …
mammals. DNA methylation plays key roles in diverse biological processes such as X …
Evaluation of affinity-based genome-wide DNA methylation data: effects of CpG density, amplification bias, and copy number variation
DNA methylation is an essential epigenetic modification that plays a key role associated with
the regulation of gene expression during differentiation, but in disease states such as …
the regulation of gene expression during differentiation, but in disease states such as …
Epigenetic biomarker development
C Bock - Epigenomics, 2009 - Taylor & Francis
Epigenetic mechanisms control gene expression in a way that is stably propagated over
multiple cell divisions, but which is also flexible enough to respond to environmental …
multiple cell divisions, but which is also flexible enough to respond to environmental …