Radical oxygen species (ROS) generate various modified DNA bases. Among them 8-oxo-7,
8-dihydroguanine (8oxoG) is the most abundant and seems to play a major role in …

Repair of both normal and reduced AP sites is activated by AP endonuclease, which
recognizes and cleaves a phosphodiester bond 5′ to the AP site. For a short period of time …

Resveratrol (3, 4′, 5-trihydroxy-trans-stilbene) is a natural phytoalexin found in grapes and
wine, which shows antioxidant and antiproliferative activities. In this study we have …

While testing purines related to the non‐specific protein kinase inhibitors N6‐
dimethylaminopurine and N6‐( 2‐isopentenyl) adenine as potential inhibitors of the …

IN mammalian cells, DNA damage increases the levels of the nuclear tumour-suppressor
p53, resulting in elevated synthesis of p21, an inhibitor of cyclin-dependent kinases (CDK) 1 …

Exposure of cellular DNA to reactive oxygen species generates several classes of base
lesions, many of which are removed by the base excision-repair pathway. However, the …

During human nucleotide excision repair, damage is recognized, two incisions are made
flanking a DNA lesion, and residues are replaced by repair synthesis. A set of proteins …

The extent and location of DNA repair synthesis in a double-stranded oligonucleotide
containing a single dUMP residue have been determined. Gently prepared Escherichia coli …

Specialized DNA polymerases (DNA pols) are required for lesion bypass in human cells.
Auxiliary factors have an important, but so far poorly understood, role. Here we analyse the …

The DNA polymerase accessory factor proliferating cell nuclear antigen (PCNA) has been
caught in interaction with an ever increasing number of proteins. To characterize the sites …