Abdominal aortic aneurysm (AAA) is a multifactorial disease with a strong genetic
component. Since the first candidate gene studies were published 20 years ago …

Objective/Background Many associations between abdominal aortic aneurysm (AAA) and
genetic polymorphisms have been reported. It is unclear which are genuine and which may …

This review considers the 250+ papers concerning the association of the angiotensin
converting enzyme (ACE) gene insertion/deletion polymorphism (rs1799752) and various …

Abdominal aortic aneurysm (AAA) is a common disease associated with significant
cardiovascular morbidity and mortality. The pathogenesis of AAA is poorly defined, making …

Background Abdominal aortic aneurysm (AAA) formation involves an inflammatory and
proteolytic process. Previous studies suggest that AAA is a multifactorial disease with a …

Background: Abdominal aortic aneurysm (AAA) is a complex disease with a largely
unknown pathophysiological background and a strong genetic component. Various studies …

Background The natural history of abdominal aortic aneurysms (AAAs) suggests that some
remain slow in growth rate whereas many develop a more accelerated growth rate and …

Objective/Background Evidence has accumulated that multiple polymorphisms in the
transforming growth factor (TGF)-β pathway and renin–angiotensin system play important …

Objective: Activation of matrix metalloproteinases and the renin/angiotensin signaling
pathways is under investigation with regard to their potential pathogenesis in dilatative …

Thoracic aortic dissection (TAD) is a catastrophic cardiovascular disease and is thought to
have a genetic basis. Various studies have indicated that renin-angiotensin system plays an …