RNA modifications can be added or removed by a variety of enzymes that catalyse the
necessary reactions, and these modifications play roles in essential molecular mechanisms …

Transcription, translation and subsequent protein modification represent the transfer of
genetic information from the archival copy of DNA to the short-lived messenger RNA, usually …

It has been suggested that cancer represents an alteration in DNA, heritable by progeny
cells, that leads to abnormally regulated expression of normal cellular genes; DNA …

In the first half of the twentieth century, developmental biology and genetics were separate
disciplines. The word epigenetics was coined by Waddington to link the two fields …

Abstract The overall 5-methylcytosine (m5C) content of DNA from normal tissues varies
considerably in a tissue-specific manner. By high-performance liquid chromatography, we …

Preventing an unacceptably high mutation rate is a challenge to the cell. Enzymatic
mechanisms of great intricacy have evolved to ensure that DNA is replicated with high …

INTRODUCTION Bacteria in their natural environment are faced with predation by both
macro-and micro-organisms. Some of the more important of the predators are the …

Publisher Summary This chapter focuses on 5-methylcytosine, gene regulation, and cancer.
The regulation of mammalian gene expression clearly is accomplished by multiple control …

Simple Summary Genes can be inactivated by specific modifications of DNA bases, most
often by adding a methyl group to the DNA base cytosine if it is followed by guanosine (CG …

Gliomas are highly malignant tumors accounting for the majority of brain neoplasms. They
are characterized by nuclear atypia, high mitotic rate and cellular polymorphism that often …