Epigenetic phenomena in animals and plants are mediated by DNA methylation and stable
chromatin modifications. There has been considerable interest in whether environmental …

Despite the success of genome-wide association studies (GWASs) in identifying loci
associated with common diseases, a substantial proportion of the causality remains …

Differential methylation of the two parental genomes in placental mammals is essential for
genomic imprinting and embryogenesis. To systematically study this epigenetic process, we …

The burgeoning interest in the field of epigenetics has precipitated the need to develop
approaches to strengthen causal inference when considering the role of epigenetic …

The variation in local rates of mutations can affect both the evolution of genes and their
function in normal and cancer cells. Deciphering the molecular determinants of this variation …

Inter-individual DNA methylation variations were frequently hypothesized to alter individual
susceptibility to Type 2 Diabetes Mellitus (T2DM). Sequence-influenced methylations were …

Studies on genetic–epigenetic interactions, including the mapping of methylation
quantitative trait loci (mQTLs) and haplotype-dependent allele-specific DNA methylation …

The interplay between genetic and epigenetic variation is only partially understood. One
form of epigenetic variation is methylation at CpG sites, which can be measured as …

Haplotype-dependent allele-specific methylation (hap-ASM) can impact disease
susceptibility, but maps of this phenomenon using stringent criteria in disease-relevant …

DNA methylation is an important molecular-level phenotype that links genotypes and
complex disease traits. Previous studies have found local correlation between genetic …