Abstract Background Essential trace elements (ETEs) play essential roles in vital functions,
but their effects on epigenetic aging remain poorly understood. Objectives This study aimed …

Biological clock technologies are designed to assess the acceleration of biological age (B-
age) in diverse cell types, offering a distinctive opportunity in toxicogenomic research to …

Objective Exposure to pesticides is a risk factor for various diseases, yet its association with
biological aging remains unclear. We aimed to systematically investigate the relationship …

Analysis of essential and non-essential trace elements in urine has emerged as a valuable
tool for assessing occupational and environmental exposures, diagnosing nutritional status …

Evidence on the effects of internal chemical mixture exposures on biological age is limited. It
also remains unclear whether hormone homeostasis and lifestyle factors can modify such a …

Dietary intake can modify the impact of metals on human health, and is also closely related
to glucose metabolism in human bodies. However, research on their interaction is limited …

Epigenetic gestational age acceleration (EGAA) at birth and epigenetic age acceleration
(EAA) in childhood may be biomarkers of the intrauterine environment. We investigated the …

Accumulation of heavy metals in the body has been shown to affect the phenotypic age
(PhenoAge). However, the combined and threshold effects of blood heavy metals on the risk …

Introduction Biological age reflects inter-individual differences in biological function and
capacity beyond chronological age. Biological age can be estimated by DNA methylation …