While Nature harnesses RNA and DNA to store, read and write genetic information, the
inherent programmability, synthetic accessibility and wide functionality of these nucleic acids …

Genomes of complex organisms encode an abundance and diversity of long noncoding
RNAs (lncRNAs) that are expressed throughout the cell and fulfill a wide variety of regulatory …

Antisense transcription, which was initially considered by many as transcriptional noise, is
increasingly being recognized as an important regulator of gene expression. It is …

The application of a new generation of sequencing techniques has revealed that most of the
genome has already been transcribed. However, only a small part of the genome codes …

Several nuclear localised intergenic long noncoding RNAs (lncRNAs) have been ascribed
regulatory roles in transcriptional control and their number is growing rapidly. Initially, these …

The past decade has seen a major increase in the study of noncoding RNAs (ncRNAs).
However, there remains a great deal of confusion and debate over the levels of functionality …

The chromosome 9p21 (Chr9p21) locus of coronary artery disease has been identified in
the first surge of genome-wide association and is the strongest genetic factor of …

Long noncoding RNAs (lncRNAs) play a pivotal role in the regulation of biological
processes through various mechanisms that are not fully understood. Proposed …

Epigenetic gene silencing is seen in several repeat-expansion diseases. In fragile X
syndrome, the most common genetic form of mental retardation, a CGG trinucleotide–repeat …

RNA can fold back on itself to adopt a wide range of structures. These range from relatively
simple hairpins to intricate 3D folds and can be accompanied by regulatory interactions with …