Polycystic kidney diseases are inherited renal disorders due mainly to mutations in genes
that regulate the development and function of cells that line renal tubules. This review …

Polycystic kidney disease (PKD), a common genetic cause of chronic renal failure in
children and adults, is characterized by the accumulation of fluid-filled cysts in the kidney …

Cystic renal diseases are caused by mutations of proteins that share a unique subcellular
localization: the primary cilium of tubular epithelial cells. Mutations of the ciliary protein …

Since its discovery as a protein associated with the cytoplasmic region of E‐cadherin, β‐
catenin has been shown to perform two apparently unrelated functions: it has a crucial role …

Polycystic kidney disease (PKD) is the most common genetic cause of renal failure in
humans. Several proteins that are encoded by genes associated with PKD have recently …

The zebrafish (Danio rerio) is now the pre-eminent vertebrate model system for clarification
of the roles of specific genes and signaling pathways in development. The zebrafish …

The stereotyped mating behaviour of the Caenorhabditis elegans male is made up of
several substeps: response, backing, turning, vulva location, spicule insertion and sperm …

Publisher Summary Nephronophthisis (NPHP) is an autosomal recessive cystic kidney
disease that represents the most frequent monogenic cause of end-stage renal disease …

Although first described as early as 1898 and long considered a vestigial organelle of little
functional importance, the primary cilium has become one of the hottest research topics in …

Cancers of the gastrointestinal tract, including the liver, bile ducts, and pancreas, constitute
the largest group of malignant tumors. Colorectal cancer is one of the most common …