[HTML][HTML] Hypoxia-inducible factor-1α: the master regulator of endothelial cell senescence in vascular aging

M Alique, E Sánchez-López, G Bodega, C Giannarelli… - Cells, 2020 - mdpi.com
Aging is one of the hottest topics in biomedical research. Advances in research and
medicine have helped to preserve human health, leading to an extension of life expectancy …

Importance of NLRP3 inflammasome in abdominal aortic aneurysms

J Shi, J Guo, Z Li, B Xu, M Miyata - Journal of atherosclerosis and …, 2021 - jstage.jst.go.jp
Abdominal aortic aneurysm (AAA) is a chronic inflammatory degenerative aortic disease,
which particularly affects older people. Nucleotide-binding oligomerization domain-like …

[HTML][HTML] Metformin prescription status and abdominal aortic aneurysm disease progression in the US veteran population

NK Itoga, KA Rothenberg, P Suarez, TV Ho… - Journal of vascular …, 2019 - Elsevier
Background Identification of a safe and effective medical therapy for abdominal aortic
aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort …

Inhibition of VEGF (vascular endothelial growth factor)-A or its receptor activity suppresses experimental aneurysm progression in the aortic elastase infusion model

B Xu, Y Iida, KJ Glover, Y Ge, Y Wang… - … , and vascular biology, 2019 - Am Heart Assoc
Objective: We examined the pathogenic significance of VEGF (vascular endothelial growth
factor)-A in experimental abdominal aortic aneurysms (AAAs) and the translational value of …

[HTML][HTML] Fibrillin-1-regulated miR-122 has a critical role in thoracic aortic aneurysm formation

RM Zhang, K Tiedemann, ML Muthu… - Cellular and Molecular …, 2022 - Springer
Thoracic aortic aneurysms (TAA) in Marfan syndrome, caused by fibrillin-1 mutations, are
characterized by elevated cytokines and fragmentated elastic laminae in the aortic wall. This …

Expression pattern and clinical value of key m6A RNA modification regulators in abdominal aortic aneurysm

T Li, T Wang, J Jing, L Sun - Journal of inflammation research, 2021 - Taylor & Francis
Background Aberrant expression of N6-methyladenosine (m6A) RNA modification
regulators plays a critical role in a variety of human diseases. However, their implication in …

Parallel murine and human aortic wall genomics reveals metabolic reprogramming as key driver of abdominal aortic aneurysm progression

G Gäbel, BH Northoff, A Balboa… - Journal of The …, 2021 - Am Heart Assoc
Background While numerous interventions effectively interfered with abdominal aortic
aneurysm (AAA) formation/progression in preclinical models, none of the successes …

[HTML][HTML] NADPH oxidases in aortic aneurysms

M Salmon - Antioxidants, 2022 - mdpi.com
Abdominal aortic aneurysms (AAAs) are a progressive dilation of the infrarenal aorta and
are characterized by inflammatory cell infiltration, smooth muscle cell migration and …

Dapagliflozin ameliorates the formation and progression of experimental abdominal aortic aneurysms by reducing aortic inflammation in mice

H Liu, P Wei, W Fu, C Xia, Y Li, K Tian… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Dapagliflozin, a sodium glucose transporter protein‐2 (SGLT‐2) inhibitor,
reduces the risk for cardiovascular diseases. However, the influence of dapagliflozin on …

EGCG attenuate EGF triggered matrix abundance and migration in HPV positive and HPV negative cervical cancer cells

R Sabanayagam, S Krishnamoorthy… - Medical Oncology, 2023 - Springer
Our previous laboratory findings suggested the beneficial effects of epigallocatechin gallate
(EGCG) against cervical cancer (CC) cells survival. The present study is aimed at identifying …