[HTML][HTML] Hypoxia-inducible factor-1α: the master regulator of endothelial cell senescence in vascular aging
Aging is one of the hottest topics in biomedical research. Advances in research and
medicine have helped to preserve human health, leading to an extension of life expectancy …
medicine have helped to preserve human health, leading to an extension of life expectancy …
Importance of NLRP3 inflammasome in abdominal aortic aneurysms
Abdominal aortic aneurysm (AAA) is a chronic inflammatory degenerative aortic disease,
which particularly affects older people. Nucleotide-binding oligomerization domain-like …
which particularly affects older people. Nucleotide-binding oligomerization domain-like …
[HTML][HTML] Metformin prescription status and abdominal aortic aneurysm disease progression in the US veteran population
Background Identification of a safe and effective medical therapy for abdominal aortic
aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort …
aneurysm (AAA) disease remains a significant unmet medical need. Recent small cohort …
Inhibition of VEGF (vascular endothelial growth factor)-A or its receptor activity suppresses experimental aneurysm progression in the aortic elastase infusion model
Objective: We examined the pathogenic significance of VEGF (vascular endothelial growth
factor)-A in experimental abdominal aortic aneurysms (AAAs) and the translational value of …
factor)-A in experimental abdominal aortic aneurysms (AAAs) and the translational value of …
[HTML][HTML] Fibrillin-1-regulated miR-122 has a critical role in thoracic aortic aneurysm formation
Thoracic aortic aneurysms (TAA) in Marfan syndrome, caused by fibrillin-1 mutations, are
characterized by elevated cytokines and fragmentated elastic laminae in the aortic wall. This …
characterized by elevated cytokines and fragmentated elastic laminae in the aortic wall. This …
Expression pattern and clinical value of key m6A RNA modification regulators in abdominal aortic aneurysm
T Li, T Wang, J Jing, L Sun - Journal of inflammation research, 2021 - Taylor & Francis
Background Aberrant expression of N6-methyladenosine (m6A) RNA modification
regulators plays a critical role in a variety of human diseases. However, their implication in …
regulators plays a critical role in a variety of human diseases. However, their implication in …
Parallel murine and human aortic wall genomics reveals metabolic reprogramming as key driver of abdominal aortic aneurysm progression
G Gäbel, BH Northoff, A Balboa… - Journal of The …, 2021 - Am Heart Assoc
Background While numerous interventions effectively interfered with abdominal aortic
aneurysm (AAA) formation/progression in preclinical models, none of the successes …
aneurysm (AAA) formation/progression in preclinical models, none of the successes …
[HTML][HTML] NADPH oxidases in aortic aneurysms
M Salmon - Antioxidants, 2022 - mdpi.com
Abdominal aortic aneurysms (AAAs) are a progressive dilation of the infrarenal aorta and
are characterized by inflammatory cell infiltration, smooth muscle cell migration and …
are characterized by inflammatory cell infiltration, smooth muscle cell migration and …
Dapagliflozin ameliorates the formation and progression of experimental abdominal aortic aneurysms by reducing aortic inflammation in mice
H Liu, P Wei, W Fu, C Xia, Y Li, K Tian… - Oxidative medicine …, 2022 - Wiley Online Library
Background. Dapagliflozin, a sodium glucose transporter protein‐2 (SGLT‐2) inhibitor,
reduces the risk for cardiovascular diseases. However, the influence of dapagliflozin on …
reduces the risk for cardiovascular diseases. However, the influence of dapagliflozin on …
EGCG attenuate EGF triggered matrix abundance and migration in HPV positive and HPV negative cervical cancer cells
R Sabanayagam, S Krishnamoorthy… - Medical Oncology, 2023 - Springer
Our previous laboratory findings suggested the beneficial effects of epigallocatechin gallate
(EGCG) against cervical cancer (CC) cells survival. The present study is aimed at identifying …
(EGCG) against cervical cancer (CC) cells survival. The present study is aimed at identifying …