TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Oxidative stress and epigenetic modifications in the pathogenesis of diabetic retinopathy
Diabetic retinopathy remains the major cause of blindness among working age adults.
Although a number of metabolic abnormalities have been associated with its development …
Although a number of metabolic abnormalities have been associated with its development …
TET (Ten-eleven translocation) family proteins: structure, biological functions and applications
X Zhang, Y Zhang, C Wang, X Wang - Signal Transduction and …, 2023 - nature.com
Ten-eleven translocation (TET) family proteins (TETs), specifically, TET1, TET2 and TET3,
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
can modify DNA by oxidizing 5-methylcytosine (5mC) iteratively to yield 5 …
Oxidative stress‐related mechanisms and antioxidant therapy in diabetic retinopathy
C Li, X Miao, F Li, S Wang, Q Liu… - … medicine and cellular …, 2017 - Wiley Online Library
Diabetic retinopathy (DR) is one of the most common microvascular complications of
diabetes and is the leading cause of blindness in young adults. Oxidative stress has been …
diabetes and is the leading cause of blindness in young adults. Oxidative stress has been …
TET proteins and the control of cytosine demethylation in cancer
L Scourzic, E Mouly, OA Bernard - Genome medicine, 2015 - Springer
The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
TET proteins and 5‐methylcytosine oxidation in hematological cancers
DNA methylation has pivotal regulatory roles in mammalian development, retrotransposon
silencing, genomic imprinting, and X‐chromosome inactivation. Cancer cells display highly …
silencing, genomic imprinting, and X‐chromosome inactivation. Cancer cells display highly …
The current state of eukaryotic DNA base damage and repair
DNA damage is a natural hazard of life. The most common DNA lesions are base, sugar,
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
and single-strand break damage resulting from oxidation, alkylation, deamination, and …
Analysis of microRNA-target interactions across diverse cancer types
A Jacobsen, J Silber, G Harinath, JT Huse… - Nature structural & …, 2013 - nature.com
Little is known about the extent to which individual microRNAs (miRNAs) regulate common
processes of tumor biology across diverse cancer types. Using molecular profiles of> 3,000 …
processes of tumor biology across diverse cancer types. Using molecular profiles of> 3,000 …
Mammalian epigenetic mechanisms
G Zhang, S Pradhan - IUBMB life, 2014 - Wiley Online Library
The mammalian genome is packaged into chromatin that is further compacted into three‐
dimensional structures consisting of distinct functional domains. The higher order structure …
dimensional structures consisting of distinct functional domains. The higher order structure …
An extensive network of TET2-targeting MicroRNAs regulates malignant hematopoiesis
Summary The Ten-Eleven-Translocation 2 (TET2) gene, which oxidates 5-methylcytosine in
DNA to 5-hydroxylmethylcytosine (5hmC), is a key tumor suppressor frequently mutated in …
DNA to 5-hydroxylmethylcytosine (5hmC), is a key tumor suppressor frequently mutated in …