Growing evidence suggests that aberrant epigenetic regulation of gene function is strongly
related to the genesis of cancer. Unlike genetic mutations, the ability to reprogram the …

Underneath the intricacy of every cancer lies mysterious events that impel the tumour cell
and its posterity into abnormal growth and tissue invasion. Oncogenic mutations disturb the …

All-trans retinoic acid (ATRA), an active metabolite of vitamin A, plays important roles in cell
proliferation, cell differentiation, apoptosis, and embryonic development. The effects of ATRA …

DNA methyltransferase inhibitors (DNMTi) approved for older AML patients are clinically
tested in combination with histone deacetylase inhibitors (HDACi). The mechanism of action …

PURPOSE DNA-hypomethylating agents are studied in combination with other epigenetic
drugs, such as histone deacetylase inhibitors or differentiation inducers (eg, retinoids), in …

What is known and objective In order to expedite the availability of drugs to treat cancers in a
cost‐effective manner, repurposing of old drugs for oncological indications is gathering …

Elderly patients with acute myeloid leukemia (AML) have limited treatment options
concerned about their overall fitness and potential treatment related mortality. Although a …

Neuroblastoma is a pediatric cancer characterized by variable outcomes ranging from
spontaneous regression to life-threatening progression. High-risk neuroblastoma patients …

Myelodysplastic syndrome (MDS) is a clonal bone marrow disorder, typically of older adults,
which is characterized by ineffective hematopoiesis, peripheral blood cytopenias and risk of …

ABSTRACT Introduction: Malignant Rhabdoid Tumor (MRT) is a rare and highly aggressive
malignancy primarily affecting infants and young children. The most common anatomic …