The blunt snout bream (Megalobrama amblycephala, BSB) is important economic fish, but it
is sensitive to hypoxia. To overcome this shortcoming, we previously obtained gynogenetic …

Therapeutic angiogenesis promises to aid the healing and regeneration of tissues suffering
from a compromised vascular supply. Ischaemia therapy has so far primarily focused on …

Introduction: Renal cell carcinoma (RCC) is the most common type of kidney cancer in
adults, and its pathogenesis is strictly related to altered cellular response to hypoxia, in …

Hypoxic signaling plays an essential role in maintaining oxygen homeostasis and cell
survival. Hypoxia-inducible transcription factors HIF-1 and HIF-2 are central mediators of the …

Oral squamous cell carcinoma (OSCC) represents 90% of malignant epithelial cancer that
occurs in the oral cavity. The c-Myc factor is expressed in multiple types of cancer …

Akt1 is critical for many in vivo functions; however, the cell-specific substrates responsible
remain to be defined. Here, we examine the importance of endothelial nitric oxide synthase …

Neovascularization is a crucial component of tumor growth and ischemia. Although prior
work primarily used disease models, delineation of neovascularization in the absence of …

Lenvatinib is an oral receptor tyrosine kinase inhibitor (TKI) with activity against vascular
endothelial growth factor (VEGF) receptors 1-3, fibroblast growth factor receptors (FGFR) 1 …

Background: It was recently shown that intermittent hypoxic-hyperoxic exposure (IHHE)
applied prior to a multimodal training program promoted additional improvements in …

The chemotactic cytokine fractalkine (FKN, chemokine CX3CL1) has unique properties
resulting from the combination of chemoattractants and adhesion molecules. The soluble …