The key role of epigenetics in human disease prevention and mitigation
AP Feinberg - New England Journal of Medicine, 2018 - Mass Medical Soc
Epigenetics in Disease Prevention and Mitigation Epigenetics is the regulation of gene
expression through alterations in DNA or associated factors (other than the DNA sequence) …
expression through alterations in DNA or associated factors (other than the DNA sequence) …
Aging hallmarks and the role of oxidative stress
E Maldonado, S Morales-Pison, F Urbina, A Solari - Antioxidants, 2023 - mdpi.com
Aging is a complex biological process accompanied by a progressive decline in the physical
function of the organism and an increased risk of age-related chronic diseases such as …
function of the organism and an increased risk of age-related chronic diseases such as …
Intragenic DNA methylation prevents spurious transcription initiation
In mammals, DNA methylation occurs mainly at CpG dinucleotides. Methylation of the
promoter suppresses gene expression, but the functional role of gene-body DNA …
promoter suppresses gene expression, but the functional role of gene-body DNA …
[PDF][PDF] N6-deoxyadenosine methylation in mammalian mitochondrial DNA
Summary N 6-Methyldeoxyadenosine (6mA) has recently been shown to exist and play
regulatory roles in eukaryotic genomic DNA (gDNA). However, the biological functions of …
regulatory roles in eukaryotic genomic DNA (gDNA). However, the biological functions of …
VDAC1 at the intersection of cell metabolism, apoptosis, and diseases
V Shoshan-Barmatz, A Shteinfer-Kuzmine, A Verma - Biomolecules, 2020 - mdpi.com
The voltage-dependent anion channel 1 (VDAC1) protein, is an important regulator of
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …
mitochondrial function, and serves as a mitochondrial gatekeeper, with responsibility for …
Epigenetic mechanisms in diabetic complications and metabolic memory
MA Reddy, E Zhang, R Natarajan - Diabetologia, 2015 - Springer
The incidence of diabetes and its associated micro-and macrovascular complications is
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …
greatly increasing worldwide. The most prevalent vascular complications of both type 1 and …
[HTML][HTML] Base-resolution analysis of 5-hydroxymethylcytosine in the mammalian genome
Summary The study of 5-hydroxylmethylcytosines (5hmC) has been hampered by the lack of
a method to map it at single-base resolution on a genome-wide scale. Affinity purification …
a method to map it at single-base resolution on a genome-wide scale. Affinity purification …
Intragenic DNA methylation modulates alternative splicing by recruiting MeCP2 to promote exon recognition
Although the function of DNA methylation in gene promoter regions is well established in
transcriptional repression, the function of the evolutionarily conserved widespread …
transcriptional repression, the function of the evolutionarily conserved widespread …
Sox2 induces glioblastoma cell stemness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications
H Lopez-Bertoni, A Johnson, Y Rui, B Lal… - Signal transduction and …, 2022 - nature.com
DNA methylation is a reversible process catalyzed by the ten–eleven translocation (TET)
family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5 …
family of enzymes (TET1, TET2, TET3) that convert 5-methylcytosine (5mC) to 5 …
Genome-wide DNA methylation analysis of human pancreatic islets from type 2 diabetic and non-diabetic donors identifies candidate genes that influence insulin …
Impaired insulin secretion is a hallmark of type 2 diabetes (T2D). Epigenetics may affect
disease susceptibility. To describe the human methylome in pancreatic islets and determine …
disease susceptibility. To describe the human methylome in pancreatic islets and determine …