Maternal obesity and fetal metabolic programming: a fertile epigenetic soil

MJR Heerwagen, MR Miller… - American Journal of …, 2010 - journals.physiology.org
The incidence of obesity and overweight has reached epidemic levels in the United States
and developed countries worldwide. Even more alarming is the increasing prevalence of …

Nanotherapy for cancer: targeting and multifunctionality in the future of cancer therapies

A Ediriwickrema, WM Saltzman - ACS biomaterials science & …, 2015 - ACS Publications
Cancer continues to be a prevalent and lethal disease, despite advances in tumor biology
research and chemotherapy development. Major obstacles in cancer treatment arise from …

Histone deacetylase (HDAC) inhibitors in recent clinical trials for cancer therapy

K Keller, M Jung - Epigenetic Therapy of Cancer: Preclinical Models and …, 2013 - Springer
Histone deacetylases are key enzymes of epigenetic regulation and are therefore involved
in crucial cellular events like transcription, differentiation, apoptosis and cell division. The …

[HTML][HTML] Epigenetics meets endocrinology

X Zhang, SM Ho - Journal of molecular endocrinology, 2011 - ncbi.nlm.nih.gov
Although genetics determines endocrine phenotypes, it cannot fully explain the great
variability and reversibility of the system in response to environmental changes. Evidence …

Epigenetic targets of bioactive dietary components for cancer prevention and therapy

SM Meeran, A Ahmed, TO Tollefsbol - Clinical epigenetics, 2010 - Springer
The emergent interest in cancer epigenetics stems from the fact that epigenetic modifications
are implicated in virtually every step of tumorigenesis. More interestingly, epigenetic …

Biological targets and mechanisms of action of natural products from marine cyanobacteria

LA Salvador-Reyes, H Luesch - Natural product reports, 2015 - pubs.rsc.org
Covering: up to 2014 Marine cyanobacteria are an ancient group of organisms and prolific
producers of bioactive secondary metabolites. These compounds are presumably optimized …

HER2 interacts with CD44 to up-regulate CXCR4 via epigenetic silencing of microRNA-139 in gastric cancer cells

W Bao, HJ Fu, QS Xie, L Wang, R Zhang, ZY Guo… - Gastroenterology, 2011 - Elsevier
BACKGROUND & AIMS: Human epidermal growth factor receptor 2 (HER2)(neu/ERBB2) is
overexpressed on many types of cancer cells, including gastric cancer cells; HER2 …

Changes in binding affinity between ofloxacin and calf thymus DNA in the presence of histone H1: Spectroscopic and molecular modeling investigations

FD Sani, N Shakibapour, S Beigoli, H Sadeghian… - Journal of …, 2018 - Elsevier
The interaction between ofloxacin (Oflx) and calf thymus DNA (ct DNA) in the presence and
absence of histone H1 was investigated in Tris buffer (pH= 6.8) using UV–vis absorption and …

[图书][B] Epigenetics: How environment shapes our genes

RC Francis - 2011 - books.google.com
Goodbye, genetic blueprint.... The first book for general readers on the game-changing field
of epigenetics. The burgeoning new science of epigenetics offers a cornucopia of insights …

Epigenetic regulation of mesenchymal stem cells: a focus on osteogenic and adipogenic differentiation

CM Teven, X Liu, N Hu, N Tang, SH Kim… - Stem cells …, 2011 - Wiley Online Library
Stem cells are characterized by their capability to self‐renew and terminally differentiate into
multiple cell types. Somatic or adult stem cells have a finite self‐renewal capacity and are …