Schizophrenia is a severe neuropsychiatric disorder affecting about 1% of individuals
worldwide. Increased innate immune activation and neuronal apoptosis are common …

Simple Summary Endogenous viruses are “ancient” viruses that have coevolved with their
host species for millions of years, developing strategies to maintain an equilibrium state with …

Human endogenous retroviruses (HERVs) are transposable genomic elements generally
repressed through DNA methylation. HERVs can be demethylated and expressed in …

The innate immune system uses pattern recognition receptors to survey the intracellular and
extracellular environment for signs of infection. Viral infection is detected through the …

Exogenous RNA poses a continuous threat to genome stability and integrity across various
organisms. Accumulating evidence reveals complex mechanisms underlying the cellular …

The synergistic relationships between Cancer, Aging, and Infection, here referred to as the
CAIn Triangle, are significant determinants in numerous health maladies and mortality rates …

Human endogenous retroviruses (HERVs) originated from ancient retroviral infections of
germline cells millions of years ago and have evolved as part of the host genome. HERVs …

Long noncoding RNAs (lncRNAs), a class of noncoding RNAs with more than 200 bp in
length, are produced by pervasive transcription in mammalian genomes and regulate gene …

Human endogenous retroviruses (HERVs) make up~ 8% of the human genome, and for
millions of years, they have been subject to strict biological regulation. Many HERVs do not …

The majority of rare diseases are genetic, and regardless of advanced high-throughput
genomics-based investigations, 60% of patients remain undiagnosed. A major factor limiting …