Bruton's tyrosine kinase (BTK) is a key component of B cell receptor (BCR) signalling and
functions as an important regulator of cell proliferation and cell survival in various B cell …

Malignancies of mature B cells are quite distinctive in originating from well-differentiated
cells. Hence, it is not paradoxical that, similar to their normal counterparts, most mature B …

The molecular interactions between B-cell precursor acute lymphoblastic leukemia (pre-B
ALL) cells and stromal cells in the bone marrow that provide microenvironmentally-mediated …

Several studies provide evidences for mantle cell lymphoma (MCL) cell survival relying on B‐
cell receptor (BCR)‐mediated signalling pathways, whereas the nature of this activation is …

Drug resistance is an important obstacle to human leukemia therapeutics. Piperlongumine
has previously demonstrated the ability to suppress certain human tumor processes; …

Leukemia in dogs is a heterogeneous disease with survival ranging from days to years,
depending on the subtype. Strides have been made in both human and canine leukemia to …

The pathomechanism of chronic lymphocytic leukemia (CLL) is an interplay of genomic and
epigenomic aberrations. Next generation sequencing (NGS) identified mutations in CLL that …

Hematopoiesis is a tightly regulated process that produces all adult blood cells and immune
cells from multipotent hematopoietic stem cells (HSCs). HSCs usually remain quiescent, and …

Several studies in chronic lymphocytic leukemia (CLL) patients have reported impaired
immune cell functions, which contribute to tumor evasion and disease progression …

Chronic lymphocytic leukaemia (CLL) is an incurable malignancy of mature B cells. CLL is
important clinically in Western countries because of its commonality and because of the …