[HTML][HTML] Revolutionizing disease modeling: the emergence of organoids in cellular systems

R Silva-Pedrosa, AJ Salgado, PE Ferreira - Cells, 2023 - mdpi.com
Cellular models have created opportunities to explore the characteristics of human diseases
through well-established protocols, while avoiding the ethical restrictions associated with …

[HTML][HTML] Subcutaneous device-free islet transplantation

X Zhou, Z Xu, Y You, W Yang, BZ Feng… - Frontiers in …, 2023 - frontiersin.org
Diabetes mellitus is a chronic metabolic disease, characterized by high blood sugar levels; it
affects more than 500 million individuals worldwide. Type 1 diabetes mellitus (T1DM) is …

Revolutionary innovations in diabetes research: from biomarkers to genomic medicine

T Addissouky, M Ali… - Iranian journal of …, 2023 - publish.kne-publishing.com
Diabetes mellitus is a chronic metabolic disease characterized by hyperglycemia resulting
from inadequate insulin signaling. Current management relies on biomarkers such as …

[HTML][HTML] Light-stimulated insulin secretion from pancreatic islet-like organoids derived from human pluripotent stem cells

J Choi, E Shin, J Lee, S Devarasou, D Kim, JH Shin… - Molecular Therapy, 2023 - cell.com
Optogenetic techniques permit non-invasive, spatiotemporal, and reversible modulation of
cellular activities. Here, we report a novel optogenetic regulatory system for insulin secretion …

[HTML][HTML] Towards halal pharmaceutical: Exploring alternatives to animal-based ingredients

Y Herdiana, FF Sofian, S Shamsuddin, T Rusdiana - Heliyon, 2023 - cell.com
Halal is a crucial concept for Muslim consumers regarding consumed products, including
pharmaceutical ingredients, which are essential in modern medicine. To address the issue …

[HTML][HTML] Current status of stem cell therapy for type 1 diabetes: a critique and a prospective consideration

MA Ghoneim, MM Gabr, SM El-Halawani… - Stem Cell Research & …, 2024 - Springer
Over the past decade, there had been progress in the development of cell therapy for insulin-
dependent diabetes. Nevertheless, important hurdles that need to be overcome still remain …

[HTML][HTML] A Supportive Role of Mesenchymal Stem Cells on Insulin-Producing Langerhans Islets with a Specific Emphasis on The Secretome

RV Sionov, R Ahdut-HaCohen - Biomedicines, 2023 - mdpi.com
Type 1 Diabetes (T1D) is a chronic autoimmune disease characterized by a gradual
destruction of insulin-producing β-cells in the endocrine pancreas due to innate and specific …

Pancreatic islet transplantation: current advances and challenges

Q Wang, Y Huang, L Liu, X Zhao, Y Sun… - Frontiers in …, 2024 - frontiersin.org
Diabetes is a prevalent chronic disease that traditionally requires severe reliance on
medication for treatment. Oral medication and exogenous insulin can only temporarily …

Silencing of forkhead box protein O-1 (FOXO-1) enhances insulin-producing cell generation from adipose mesenchymal stem cells for diabetes therapy

MM Kamal, RA Ammar, DH Kassem - Life Sciences, 2024 - Elsevier
Aims Generation of mature β-cells from MSCs has been a challenge in the field of stem cell
therapy of diabetes. Adipose tissue-derived mesenchymal stem cells (Ad-MSCs) have made …

[HTML][HTML] Low molecular weight chitosan (∼ 20kDa) exhibits in vivo anti-hyperglycemic effects through AKT/PI3K/FOXO pathway

DN Priyanka, KVH Prashanth - Carbohydrate Polymer Technologies and …, 2024 - Elsevier
Diabetes, a metabolic syndrome, is a leading global cause of morbidity and mortality.
Dietary polysaccharide intervention besides medication, helps in diabetes through …