Bone, cartilage, and soft tissue regeneration is a complex spatiotemporal process recruiting
a variety of cell types, whose activity and interplay must be precisely mediated for effective …

Hypoxia is an inadequate oxygen supply to tissues and cells, which can restrict their
function. The hypoxic response is primarily mediated by the hypoxia-inducible transcription …

Background The primary issue arising from prostate cancer (PCa) is its high prevalence to
metastasize to bone, which severely affects the quality of life and survival time of PCa …

Three-dimensional (3D) bioprinting is an additive manufacturing process that utilizes various
biomaterials that either contain or interact with living cells and biological systems with the …

Background: Angiogenesis is likely critical for the process of intramembranous
osteogenesis; however, the developmental relationship between blood vessels and bone …

Adaptation to hypoxia is a critical cellular event both in pathological settings, such as cancer
and ischaemia, and in normal development and differentiation. Oxygen is thought to be not …

Bottom-up biofabrication approaches combining micro-tissue fabrication techniques with
extrusion-based 3D printing of thermoplastic polymer scaffolds are emerging strategies in …

Oxygen homeostasis reflects the constant body requirement to generate energy. Hypoxia
(0.1–1% O2), physioxia or physoxia (∼ 1–13%), and normoxia (∼ 20%) are terms used to …

Despite the major progresses in biomedical research and the development of novel
therapeutics and treatment strategies, cancer is still among the dominant causes of death …

Hypoxia inducible factors (HIFs) are transcription factors, which are commonly expressed in
mammals, including humans. The HIFs consist of hypoxia-regulated α and oxygen …