Cellular and epigenetic drivers of stem cell ageing
Adult tissue stem cells have a pivotal role in tissue maintenance and regeneration
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …
throughout the lifespan of multicellular organisms. Loss of tissue homeostasis during post …
[HTML][HTML] Overweight and obesity in pregnancy: their impact on epigenetics
C Reichetzeder - European journal of clinical nutrition, 2021 - nature.com
Over the last few decades, the prevalence of obesity has risen to epidemic proportions
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …
worldwide. Consequently, the number of obesity in pregnancy has risen drastically …
[HTML][HTML] Redistribution of H3K27me3 upon DNA hypomethylation results in de-repression of Polycomb target genes
JP Reddington, SM Perricone, CE Nestor… - Genome biology, 2013 - Springer
Background DNA methylation and the Polycomb repression system are epigenetic
mechanisms that play important roles in maintaining transcriptional repression. Recent …
mechanisms that play important roles in maintaining transcriptional repression. Recent …
MLL2 conveys transcription-independent H3K4 trimethylation in oocytes
CW Hanna, A Taudt, J Huang, L Gahurova… - Nature structural & …, 2018 - nature.com
Histone 3 K4 trimethylation (depositing H3K4me3 marks) is typically associated with active
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …
promoters yet paradoxically occurs at untranscribed domains. Research to delineate the …
[HTML][HTML] Increased global placental DNA methylation levels are associated with gestational diabetes
C Reichetzeder, SE Dwi Putra, T Pfab, T Slowinski… - Clinical …, 2016 - Springer
Background Gestational diabetes mellitus (GDM) is associated with adverse pregnancy
outcomes. It is known that GDM is associated with an altered placental function and changes …
outcomes. It is known that GDM is associated with an altered placental function and changes …
Transcriptional and epigenetic regulation of T‐helper lineage specification
SK Tripathi, R Lahesmaa - Immunological reviews, 2014 - Wiley Online Library
Combined with TCR stimuli, extracellular cytokine signals initiate the differentiation of naive
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …
CD 4+ T cells into specialized effector T‐helper (Th) and regulatory T (Treg) cell subsets …
Nucleosome repositioning links DNA (de) methylation and differential CTCF binding during stem cell development
VB Teif, DA Beshnova, Y Vainshtein, C Marth… - Genome …, 2014 - genome.cshlp.org
During differentiation of embryonic stem cells, chromatin reorganizes to establish cell type-
specific expression programs. Here, we have dissected the linkages between DNA …
specific expression programs. Here, we have dissected the linkages between DNA …
Analysis of DNA methylation reveals a partial reprogramming of the Müller glia genome during retina regeneration
C Powell, AR Grant, E Cornblath… - Proceedings of the …, 2013 - National Acad Sciences
Upon retinal injury, zebrafish Müller glia (MG) transition from a quiescent supportive cell to a
progenitor cell (MGPC). This event is accompanied by the induction of key transcription and …
progenitor cell (MGPC). This event is accompanied by the induction of key transcription and …
DNMT1 maintains metabolic fitness of adipocytes through acting as an epigenetic safeguard of mitochondrial dynamics
White adipose tissue (WAT) is a key regulator of systemic energy metabolism, and impaired
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …
WAT plasticity characterized by enlargement of preexisting adipocytes associates with WAT …
基因组DNA 甲基化及组蛋白甲基化
王瑞娴， 徐建红 - 遗传, 2014 - chinagene.cn
在真核生物中, DNA 甲基化是一种非常重要的表观遗传学标记, 能影响染色质的结构和基因的
表达. 随着全基因组甲基化测序的发展, 全基因组范围内的DNA 甲基化水平得以了解 …
表达. 随着全基因组甲基化测序的发展, 全基因组范围内的DNA 甲基化水平得以了解 …