In vitro and in vivo effects of IGF-1 delivery strategies on tendon healing: a review

I Miescher, J Rieber, M Calcagni… - International Journal of …, 2023 - mdpi.com
Tendon injuries suffer from a slow healing, often ending up in fibrovascular scar formation,
leading to inferior mechanical properties and even re-rupture upon resumption of daily work …

The spatial landscape of progression and immunoediting in primary melanoma at single-cell resolution

AJ Nirmal, Z Maliga, T Vallius, B Quattrochi, AA Chen… - Cancer Discovery, 2022 - AACR
Cutaneous melanoma is a highly immunogenic malignancy that is surgically curable at early
stages but life-threatening when metastatic. Here we integrate high-plex imaging, 3D high …

RNA binding proteins in senescence: a potential common linker for age-related diseases?

A Varesi, LIM Campagnoli, A Barbieri, L Rossi… - Ageing Research …, 2023 - Elsevier
Aging represents the major risk factor for the onset and/or progression of various disorders
including neurodegenerative diseases, metabolic disorders, and bone-related defects. As …

Single-cell sequencing reveals the landscape of the human brain metastatic microenvironment

Q Song, J Ruiz, F Xing, HW Lo, L Craddock… - Communications …, 2023 - nature.com
Brain metastases is the most common intracranial tumor and account for approximately 20%
of all systematic cancer cases. It is a leading cause of death in advanced-stage cancer …

[HTML][HTML] Viscoelastic hydrogels for interrogating pancreatic cancer-stromal cell interactions

FY Lin, CY Chang, H Nguyen, H Li, ML Fishel… - Materials Today Bio, 2023 - Elsevier
The tumor microenvironment (TME) is known to direct cancer cell growth, migration, invasion
into the matrix and distant tissues, and to confer drug resistance in cancer cells. While …

Solid diet manipulates rumen epithelial microbiota and its interactions with host transcriptomic in young ruminants

J Chai, X Lv, Q Diao, H Usdrowski… - Environmental …, 2021 - Wiley Online Library
Solid diet supplementation in the early life stages of ruminants could improve rumen
microbiota and tissue development. However, most studies focus on bacteria in the rumen …

SNAIL2 contributes to tumorigenicity and chemotherapy resistance in pancreatic cancer by regulating IGFBP2

K Masuo, R Chen, A Yogo, A Sugiyama… - Cancer …, 2021 - Wiley Online Library
Pancreatic cancer has an extremely poor prognosis because of its resistance to
conventional therapies. Cancer stem cell (CSC)‐targeted therapy is considered a promising …

[HTML][HTML] Single-cell landscape reveals the epithelial cell-centric pro-inflammatory immune microenvironment in dry eye development

Z Liu, H Xie, L Li, D Jiang, Y Qian, X Zhu, M Dai, Y Li… - Mucosal …, 2024 - Elsevier
Dry eye disease (DED) is a prevalent chronic eye disease characterized by an aberrant
inflammatory response in ocular surface mucosa. The immunological alterations underlying …

NCBP2 and TFRC are novel prognostic biomarkers in oral squamous cell carcinoma

R Arora, L Haynes, M Kumar, R McNeil, J Ashkani… - Cancer gene …, 2023 - nature.com
There are few prognostic biomarkers and targeted therapeutics currently in use for the
clinical management of oral squamous cell carcinoma (OSCC) and patient outcomes remain …

Promoting prognostic model application: a review based on gliomas

X Liang, Z Wang, Z Dai, H Zhang, Q Cheng… - Journal of …, 2021 - Wiley Online Library
Malignant neoplasms are characterized by poor therapeutic efficacy, high recurrence rate,
and extensive metastasis, leading to short survival. Previous methods for grouping …