Curcumin—from molecule to biological function

T Esatbeyoglu, P Huebbe, IMA Ernst… - Angewandte Chemie …, 2012 - Wiley Online Library
Turmeric is traditionally used as a spice and coloring in foods. It is an important ingredient in
curry and gives curry powder its characteristic yellow color. As a consequence of its intense …

Sulforaphane: its “coming of age” as a clinically relevant nutraceutical in the prevention and treatment of chronic disease

CA Houghton - Oxidative medicine and cellular longevity, 2019 - Wiley Online Library
A growing awareness of the mechanisms by which phytochemicals can influence upstream
endogenous cellular defence processes has led to intensified research into their potential …

Plants vs. cancer: a review on natural phytochemicals in preventing and treating cancers and their druggability

H Wang, T Oo Khor, L Shu, ZY Su… - Anti-Cancer Agents …, 2012 - ingentaconnect.com
Cancer remains to be one of the leading causes of death in the United States and around
the world. The advent of modern drug-targeted therapies has undeniably improved cancer …

Targeting drug chemo-resistance in cancer using natural products

WH Talib, AR Alsayed, M Barakat, MI Abu-Taha… - Biomedicines, 2021 - mdpi.com
Cancer is one of the leading causes of death globally. The development of drug resistance
is the main contributor to cancer-related mortality. Cancer cells exploit multiple mechanisms …

Ubiquitylation in apoptosis: a post-translational modification at the edge of life and death

D Vucic, VM Dixit, IE Wertz - Nature reviews Molecular cell biology, 2011 - nature.com
The proper regulation of apoptosis is essential for the survival of multicellular organisms.
Furthermore, excessive apoptosis can contribute to neurodegenerative diseases, anaemia …

Dietary metabolites derived from gut microbiota: critical modulators of epigenetic changes in mammals

MI Bhat, R Kapila - Nutrition reviews, 2017 - academic.oup.com
The mammalian gastrointestinal tract harbors trillions of commensal microorganisms,
collectively known as the microbiota. The microbiota is a critical source of environmental …

The functional diversity of protein lysine methylation

S Lanouette, V Mongeon, D Figeys… - Molecular systems …, 2014 - embopress.org
Large‐scale characterization of post‐translational modifications (PTM s), such as
phosphorylation, acetylation and ubiquitination, has highlighted their importance in the …

Epigenetic impact of dietary polyphenols in cancer chemoprevention: lifelong remodeling of our epigenomes

WV Berghe - Pharmacological research, 2012 - Elsevier
Cancer, as one of the non-communicable diseases, remains one of the leading causes of
death around the world. Recently, epigenetic changes in DNA methylation patterns at CpG …

Diet, the gut microbiome, and epigenetics

MAJ Hullar, BC Fu - The Cancer Journal, 2014 - journals.lww.com
Increasingly, the gut microbiome is implicated in the etiology of cancer, not only as an
infectious agent but also by altering exposure to dietary compounds that influence disease …

Dietary phytochemicals as epigenetic modifiers in cancer: Promise and challenges

E Shankar, R Kanwal, M Candamo, S Gupta - Seminars in cancer biology, 2016 - Elsevier
The influence of diet and environment on human health has been known since ages. Plant-
derived natural bioactive compounds (phytochemicals) have acquired an important role in …