The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

We summarize in this article the experiments which have been performed to test the
theoretical findings in stochastic thermodynamics such as fluctuation theorem, Jarzynski …

DNA methylation is a heritable epigenetic modification involved in gene silencing,
imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in …

Gene activation requires the cooperative activity of multiple transcription factors at cis-
regulatory elements (CREs). Yet, most transcription factors have short residence time …

In mammals, cytosine methylation (5mC) is widely distributed throughout the genome but is
notably depleted from active promoters and enhancers. While the role of DNA methylation in …

Summary Tet enzymes (Tet1/2/3) convert 5-methylcytosine (5mC) to 5-
hydroxymethylcytosine (5hmC) and are dynamically expressed during development …

DNA methylation is one of the most extensively studied epigenetic marks. It is involved in
transcriptional gene silencing and plays important roles during mammalian development. Its …

DNA methylation is a major epigenetic modification of vertebrate genomes that is mostly
associated with transcriptional repression. During embryogenesis, DNA methylation …

Minority subpopulations within embryonic stem cell cultures display an expanded
developmental potential similar to that of early embryo blastomeres or the early inner cell …

DNA methylation is an essential mechanism controlling gene expression during
differentiation and development. We investigated the epigenetic regulation of the nuclear …