Matrix metalloproteinases (MMPs) appear to be ideal drug targets—they are disease-
associated, extracellular enzymes with a dependence on zinc for activity. This apparently …

The matrix metalloproteinase family of enzymes has been a pharmaceutical target for over
20 years. In that time, many drugs have been developed but none have successfully passed …

Triple‐negative breast cancer (TNBC) patients have a predisposition to poor prognosis due
to the strong malignancy. Ferroptosis, a new form of cell death, is a candidate treatment for …

OBJECTIVE: To evaluate the effect of statins on aneurysm growth in a group of consecutive
patients under surveillance for infrarenal aortic aneurysms (AAA). MATERIALS AND …

Current management of aortic aneurysms relies exclusively on prophylactic operative repair
of larger aneurysms. Great potential exists for successful medical therapy that halts or …

BACKGROUND: Statins have been suggested to reduce expansion of abdominal aortic
aneurysms (AAAs) independent of lipid-lowering effects. METHODS: We assessed the …

Abdominal aortic aneurysm (AAA) is a chronic vascular degenerative disease featured by
progressive dilation and remodeling of the vascular wall, which may lead to aortic rupture …

Background The aim was to investigate the effects of statin therapy on abdominal aortic
aneurysm (AAA) disease. Methods PubMed, the Cochrane Library, Embase and …

Thoracic aortic aneurysms (TAAs) are a rare but potentially devastating condition. Current
surgical treatment of TAAs usually involves a major operation, which conveys many risks to …

Human ageing is determined by degenerative alterations and processes with different
manifestations such as gradual organ dysfunction, tissue function loss, increased population …