An important mechanism of nutritional “programming” induced by supplementation with
methyl donors during pregnancy is the alteration of mRNA abundance in the offspring. We …

As a chronic metabolic disease affecting epidemic proportions worldwide, the pathogenesis
of Nonalcoholic Fatty Liver Disease (NAFLD) is not clear yet. There is also a lack of precise …

BACKGROUND & AIMS: Steatohepatitis (SH) is associated with mitochondrial dysfunction
and excessive production of superoxide, which can then be converted into H2O2 by SOD2 …

Deletion of glycine N‐methyltransferase (GNMT), the main gene involved in liver S‐
adenosylmethionine (SAM) catabolism, leads to the hepatic accumulation of this molecule …

Metabolic engineering of microorganisms for production of biological molecules represent a
key goal for industrial biotechnology. The metabolic engineering requires detailed …

We compared the relative protective abilities of silymarin and l-methionine pre-treatment in
acetaminophen overdose injuries of the liver, kidney and cerebral cortex by assessing …

Nuclear receptors play pleiotropic roles in cell differentiation, development, proliferation, and
metabolic processes to govern liver physiology and pathology. The nuclear receptor, liver …

Chronic ethanol infusion resulted in greater serum alanine aminotransferase elevation, lipid
accumulation, necroinflammation, and focal hepatic cell death in mice than rats. Mice …

The compounds of sphingomyelin-ceramide-glycosphingolipid pathways have been studied
as potential secondary messenger molecules in various systems, along with liver function …

LKB1, originally considered a tumor suppressor, plays an important role in hepatocyte
proliferation and liver regeneration. Mice lacking the methionine adenosyltransferase (MAT) …