The fibrogenic niche in kidney fibrosis: components and mechanisms
L Li, H Fu, Y Liu - Nature Reviews Nephrology, 2022 - nature.com
Kidney fibrosis, characterized by excessive deposition of extracellular matrix (ECM) that
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …
leads to tissue scarring, is the final common outcome of a wide variety of chronic kidney …
Targeting the progression of chronic kidney disease
Chronic kidney disease (CKD) is a devastating condition that is reaching epidemic levels
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
owing to the increasing prevalence of diabetes mellitus, hypertension and obesity, as well …
[HTML][HTML] Signaling pathways involved in diabetic renal fibrosis
Y Zhang, D Jin, X Kang, R Zhou, Y Sun… - Frontiers in cell and …, 2021 - frontiersin.org
Diabetic kidney disease (DKD), as the most common complication of diabetes mellitus (DM),
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …
is the major cause of end-stage renal disease (ESRD). Renal interstitial fibrosis is a crucial …
[HTML][HTML] Ten years of extracellular matrix proteomics: accomplishments, challenges, and future perspectives
A Naba - Molecular & Cellular Proteomics, 2023 - ASBMB
The extracellular matrix (ECM) is a complex assembly of hundreds of proteins forming the
architectural scaffold of multicellular organisms. In addition to its structural role, the ECM …
architectural scaffold of multicellular organisms. In addition to its structural role, the ECM …
[HTML][HTML] A diabetic milieu increases ACE2 expression and cellular susceptibility to SARS-CoV-2 infections in human kidney organoids and patient cells
It is not well understood why diabetic individuals are more prone to develop severe COVID-
19. To this, we here established a human kidney organoid model promoting early hallmarks …
19. To this, we here established a human kidney organoid model promoting early hallmarks …
Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis
R Nørregaard, HAM Mutsaers… - Physiological …, 2023 - journals.physiology.org
The kidneys play a key role in maintaining total body homeostasis. The complexity of this
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …
task is reflected in the unique architecture of the organ. Ureteral obstruction greatly affects …
Ion channels and channelopathies in glomeruli
A Staruschenko, R Ma, O Palygin… - Physiological …, 2023 - journals.physiology.org
An essential step in renal function entails the formation of an ultrafiltrate that is delivered to
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
the renal tubules for subsequent processing. This process, known as glomerular filtration, is …
Kidney fibrosis: Emerging diagnostic and therapeutic strategies
BM Klinkhammer, P Boor - Molecular Aspects of Medicine, 2023 - Elsevier
An increasing number of patients worldwide suffers from chronic kidney disease (CKD).
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …
CKD is accompanied by kidney fibrosis, which affects all compartments of the kidney, ie, the …
[HTML][HTML] Kidney-based in vitro models for drug-induced toxicity testing
The kidney is frequently involved in adverse effects caused by exposure to foreign
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …
compounds, including drugs. An early prediction of those effects is crucial for allowing novel …
Artificial intelligence-assisted repurposing of lubiprostone alleviates tubulointerstitial fibrosis
Tubulointerstitial fibrosis (TIF) is the most prominent cause which leads to chronic kidney
disease (CKD) and end-stage renal failure. Despite extensive research, there have been …
disease (CKD) and end-stage renal failure. Despite extensive research, there have been …