Galectins are a family of endogenous glycan-binding proteins that have crucial roles in a
broad range of physiological and pathological processes. As a group, these proteins use …

Vascular smooth muscle cells (VSMCs), the major cell type in the arterial vessel wall, have a
contractile phenotype that maintains the normal vessel structure and function under …

The CXC chemokine receptor 4 (CXCR4) in endothelial cells (ECs) and vascular smooth
muscle cells (VSMCs) is crucial for vascular integrity. The atheroprotective functions of …

Vascular remodeling is a common pathological hallmark of many cardiovascular diseases.
Vascular smooth muscle cells (VSMCs) are the predominant cell type lining the tunica media …

Background DNA-dependent protein kinase catalytic subunit (DNA-PKcs) is a novel
instigator for mitochondrial dysfunction, and plays an important role in the pathogenesis of …

The extracellular matrix (ECM) is an intricate network composed of various multi-domain
macromolecules like collagen, proteoglycans, and fibronectin, etc., that form a structurally …

Protein glycosylation controls cell–cell and cell–extracellular matrix (ECM) communication in
immune, vascular, and inflammatory processes, underlining the critical role of this process in …

Abstract Angiopoietin-like protein 8 (ANGPTL8) plays important roles in lipid metabolism,
glucose metabolism, inflammation, and cell proliferation and migration. Clinical studies have …

The lymphatic vasculature provides an essential route to drain fluid, macromolecules, and
immune cells from the interstitium as lymph, returning it to the bloodstream where the …

Background The occurrence of abdominal aortic aneurysms (AAAs) is related to the disorder
of immune microenvironment. Cuprotosis was reported to influence the immune …