Epigenetic modifications are crucial for the identity and stability of cells, and, when aberrant,
can lead to disease. During mouse development, the genome-wide epigenetic states of pre …

DNA methylation can cause heritable phenotypic modifications in the absence of changes in
DNA sequence. Environmental stresses can trigger methylation changes and this may have …

A complex interplay between multiple biological effects shapes the aging process. The
advent of genome-wide quantitative approaches in the epigenetic field has highlighted the …

Epigenetic marking systems confer stability of gene expression during mammalian
development. Genome-wide epigenetic reprogramming occurs at stages when …

Genome-wide epigenetic reprogramming in mammalian germ cells, zygote and early
embryos, plays a crucial role in regulating genome functions at critical stages of …

The past decade has seen a tremendous increase in interest and progress in the field of
sperm epigenetics. Studies have shown that chromatin regulation during male germline …

Zygotic epigenetic reprogramming entails genome-wide DNA demethylation that is
accompanied by Tet methylcytosine dioxygenase 3 (Tet3)-driven oxidation of 5 …

The hiatus between oocyte and embryonic gene transcription dictates a role for stored
maternal factors in early mammalian development. Encoded by maternal-effect genes, these …

BACKGROUND The placenta is of utmost importance for intrauterine fetal development and
growth. Deregulation of placentation can lead to adverse outcomes for both mother and …

Understanding preimplantation development is important both for basic reproductive biology
and for practical applications including regenerative medicine and livestock breeding …