Abdominal aortic aneurysm: roles of inflammatory cells

Z Yuan, Y Lu, J Wei, J Wu, J Yang, Z Cai - Frontiers in immunology, 2021 - frontiersin.org
Abdominal aortic aneurysms (AAAs) are local dilations of infrarenal segment of aortas.
Molecular mechanisms underlying the pathogenesis of AAA remain not fully clear. However …

Vascular smooth muscle cells in aortic aneurysm: from genetics to mechanisms

H Lu, W Du, L Ren, MH Hamblin… - Journal of the …, 2021 - Am Heart Assoc
Aortic aneurysm, including thoracic aortic aneurysm and abdominal aortic aneurysm, is the
second most prevalent aortic disease following atherosclerosis, representing the ninth …

Gut microbiome dysbiosis contributes to abdominal aortic aneurysm by promoting neutrophil extracellular trap formation

Z Tian, Y Zhang, Z Zheng, M Zhang, T Zhang, J Jin… - Cell host & …, 2022 - cell.com
Abdominal aortic aneurysm (AAA) is an insidious and lethal vascular disease that lacks
effective nonsurgical interventions. Gut microbiota dysbiosis plays key roles in many …

Extracellular matrix, regional heterogeneity of the aorta, and aortic aneurysm

S Jana, M Hu, M Shen, Z Kassiri - Experimental & molecular medicine, 2019 - nature.com
Aortic aneurysm is an asymptomatic disease with dire outcomes if undiagnosed. Aortic
aneurysm rupture is a significant cause of death worldwide. To date, surgical repair or …

NLRP3 inflammasome as a key driver of vascular disease

M Takahashi - Cardiovascular research, 2022 - academic.oup.com
Nucleotide-binding oligomerization domain-like receptor family pyrin domain containing 3
(NLRP3) is an intracellular innate immune receptor that recognizes a diverse range of …

[HTML][HTML] Senescence and senolytics in cardiovascular disease: Promise and potential pitfalls

WA Owens, A Walaszczyk, I Spyridopoulos… - Mechanisms of Ageing …, 2021 - Elsevier
Ageing is the biggest risk factor for impaired cardiovascular health, with cardiovascular
disease being the cause of death in 40% of individuals over 65 years old. Ageing is …

Genetic and epigenetic mechanisms underlying vascular smooth muscle cell phenotypic modulation in abdominal aortic aneurysm

R Gurung, AM Choong, CC Woo, R Foo… - International journal of …, 2020 - mdpi.com
Abdominal aortic aneurysm (AAA) refers to the localized dilatation of the infra-renal aorta, in
which the diameter exceeds 3.0 cm. Loss of vascular smooth muscle cells, degradation of …

Gut microbiota–derived trimethylamine N-oxide contributes to abdominal aortic aneurysm through inflammatory and apoptotic mechanisms

TW Benson, KA Conrad, XS Li, Z Wang, RN Helsley… - Circulation, 2023 - Am Heart Assoc
Background: Large-scale human and mechanistic mouse studies indicate a strong
relationship between the microbiome-dependent metabolite trimethylamine N-oxide (TMAO) …

The mechanism and therapy of aortic aneurysms

J Gao, H Cao, G Hu, Y Wu, Y Xu, H Cui, HS Lu… - Signal transduction and …, 2023 - nature.com
Aortic aneurysm is a chronic aortic disease affected by many factors. Although it is generally
asymptomatic, it poses a significant threat to human life due to a high risk of rupture …

Cigarette smoke extract induces ferroptosis in vascular smooth muscle cells

A Sampilvanjil, T Karasawa… - American Journal …, 2020 - journals.physiology.org
Cigarette smoking is a major risk factor for aortic aneurysm and dissection; however, no
causative link between smoking and these aortic disorders has been proven. In the present …