Cellular hypoxia is the common final pathway of brain injury that occurs not just after
asphyxia, but also when cerebral perfusion is impaired directly (eg, embolic stroke) or …

Objective: The management of hypoxemia in critically ill patients is challenging. Whilst the
harms of tissue hypoxia are well recognized, the possibility of harm from excess oxygen …

Hypoxia-inducible factor–prolyl hydroxylase domain inhibitors (HIF-PHIs) are a promising
new class of orally administered drugs currently in late-stage global clinical development for …

People rely on speech for communication, both in a personal and professional context, and
often under different conditions of physical, cognitive and/or emotional load. Since …

COVID-19 hinders oxygen transport to the consuming tissues by at least two mechanisms: In
the injured lung, saturation of hemoglobin is compromised, and in the tissues, an associated …

The treatment of cold injuries to the periphery has advanced substantially in the last 10
years and optimal outcomes are only likely to be achieved if a multidisciplinary team uses …

Populations residing for millennia on the high-altitude plateaus of the world started natural
experiments that we can evaluate to address questions about the processes of evolution …

High-altitude illnesses have profound consequences on the health of many unsuspecting
and otherwise healthy individuals who sojourn to high altitude for recreation and work. The …

The (patho-) physiological responses to hypoxia are highly heterogeneous between
individuals. In this review, we focused on the roles of sex differences, which emerge as …

Ortiz-Prado, Esteban, Raul Patricio Fernandez Naranjo, Eduardo Vasconez, Katherine
Simbaña-Rivera, Trigomar Correa-Sancho, Alex Lister, Manuel Calvopiña, and Ginés …