TET-mediated active DNA demethylation: mechanism, function and beyond
In mammals, DNA methylation in the form of 5-methylcytosine (5mC) can be actively
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
reversed to unmodified cytosine (C) through TET dioxygenase-mediated oxidation of 5mC to …
Mapping the epigenetic modifications of DNA and RNA
Over 17 and 160 types of chemical modifications have been identified in DNA and RNA,
respectively. The interest in understanding the various biological functions of DNA and RNA …
respectively. The interest in understanding the various biological functions of DNA and RNA …
Transgenerational inheritance of acquired epigenetic signatures at CpG islands in mice
Transgenerational epigenetic inheritance in mammals remains a debated subject. Here, we
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …
demonstrate that DNA methylation of promoter-associated CpG islands (CGIs) can be …
Regulation of transposable elements by DNA modifications
Maintenance of genome stability requires control over the expression of transposable
elements (TEs), whose activity can have substantial deleterious effects on the host …
elements (TEs), whose activity can have substantial deleterious effects on the host …
Interplay between chromatin marks in development and disease
SM Janssen, MC Lorincz - Nature Reviews Genetics, 2022 - nature.com
DNA methylation (DNAme) and histone post-translational modifications (PTMs) have
important roles in transcriptional regulation. Although many reports have characterized the …
important roles in transcriptional regulation. Although many reports have characterized the …
[PDF][PDF] In vitro reconstitution of the whole male germ-cell development from mouse pluripotent stem cells
Mammalian male germ-cell development consists of three distinct phases: primordial germ
cell (PGC) development, male germ-cell specification for spermatogonium development …
cell (PGC) development, male germ-cell specification for spermatogonium development …
Allelic reprogramming of the histone modification H3K4me3 in early mammalian development
Histone modifications are fundamental epigenetic regulators that control many crucial
cellular processes. However, whether these marks can be passed on from mammalian …
cellular processes. However, whether these marks can be passed on from mammalian …
[PDF][PDF] A unique gene regulatory network resets the human germline epigenome for development
Resetting of the epigenome in human primordial germ cells (hPGCs) is critical for
development. We show that the transcriptional program of hPGCs is distinct from that in …
development. We show that the transcriptional program of hPGCs is distinct from that in …
[PDF][PDF] The transcriptome and DNA methylome landscapes of human primordial germ cells
Germ cells are vital for transmitting genetic information from one generation to the next and
for maintaining the continuation of species. Here, we analyze the transcriptome of human …
for maintaining the continuation of species. Here, we analyze the transcriptome of human …
Specification and epigenetic programming of the human germ line
Primordial germ cells (PGCs), the precursors of sperm and eggs, are established in
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …
perigastrulation-stage embryos in mammals. Signals from extra-embryonic tissues induce a …