Rho family guanosine triphosphatases (GTPases) regulate cellular signaling and
cytoskeletal dynamics, playing a pivotal role in cell adhesion, migration, and cell cycle …

Migration is one of the five major behaviors of cells. Although RhoC—a classic member of
the Rho gene family—was first identified in 1985, functional RhoC data have only been …

Psoriasis is a chronic inflammatory skin disease closely related with T cells, and its
management remains a challenge. Novel targets and associated drugs are urgently needed …

Abstract Aicardi-Goutières Syndrome (AGS) is a rare neuro-inflammatory disease
characterized by increased expression of interferon-stimulated genes (ISGs). Disease …

Primary immunodeficiencies (PIDs) are associated with deleterious mutations of genes that
encode proteins involved in actin cytoskeleton reorganisation. This deficiency affects …

Abstract Atypical Rho GTPases are a subtype of the Rho GTPase family that are involved in
diverse cellular processes. The typical Rho GTPases, led by RhoA, Rac1 and Cdc42, have …

The role of RhoG in T cell development is redundant with other Racs subfamily members,
and this redundancy may be attributed to redundant signal transduction pathways. However …

Background Allergic rhinitis is a common inflammatory condition of the nasal mucosa that
imposes a considerable health burden. Air pollution has been observed to increase the risk …

Specific members of the Nima-Related Kinase (NEK) family have been linked to cancer
development and progression, and a role for NEK5, one of the least studied members, in …

Background The genetic architecture of JIA remains only partially comprehended. There is a
clear imperative for continued endeavours to uncover insights into the underlying causes of …