NAD+/NADH and NADP+/NADPH in Cellular Functions and Cell Death: Regulation and Biological Consequences

W Ying - Antioxidants & redox signaling, 2008 - liebertpub.com
C. NADP synthesis D. Catabolism of NAD and NADP E. Relationships between NAD and
NADP F. NAD transport across mitochondrial membranes G. NAD transport across the …

Methylation matters

JF Costello, C Plass - Journal of medical genetics, 2001 - jmg.bmj.com
DNA methylation is not just for basic scientists any more. There is a growing awareness in
the medical field that having the correct pattern of genomic methylation is essential for …

The redox basis of epigenetic modifications: from mechanisms to functional consequences

AR Cyr, FE Domann - Antioxidants & redox signaling, 2011 - liebertpub.com
Epigenetic modifications represent mechanisms by which cells may effectively translate
multiple signaling inputs into phenotypic outputs. Recent research is revealing that redox …

Epigenetics: poly (ADP‐ribosyl) ation of PARP‐1 regulates genomic methylation patterns

P Caiafa, T Guastafierro, M Zampieri - The FASEB Journal, 2009 - Wiley Online Library
In the postgenome era, attention is being focused on those epigenetic modifications that
modulate chromatin structure to guarantee that information present on DNA is read correctly …

CCCTC-binding factor activates PARP-1 affecting DNA methylation machinery

T Guastafierro, B Cecchinelli, M Zampieri… - Journal of Biological …, 2008 - ASBMB
Our previous data have shown that in L929 mouse fibroblasts the control of methylation
pattern depends in part on poly (ADP-ribosyl) ation and that ADP-ribose polymers (PARs) …

Modulation of DNMT1 activity by ADP-ribose polymers

A Reale, GD Matteis, G Galleazzi, M Zampieri, P Caiafa - Oncogene, 2005 - nature.com
We provided evidence that competitive inhibition of poly (ADP-ribose) polymerases in
mammalian cells treated with 3-aminobenzamide causes DNA hypermethylation in the …

ADP-ribose polymers localized on Ctcf–Parp1–Dnmt1 complex prevent methylation of Ctcf target sites

M Zampieri, T Guastafierro, R Calabrese… - Biochemical …, 2012 - portlandpress.com
PARylation [poly (ADP-ribosyl) ation] is involved in the maintenance of genomic methylation
patterns through its control of Dnmt1 [DNA (cytosine-5)-methyltransferase 1] activity. Our …

DNA methylation and chromatin structure: the puzzling CpG islands

P Caiafa, M Zampieri - Journal of cellular biochemistry, 2005 - Wiley Online Library
DNA methylation is the epigenetic modification, which introduces 5mC as fifth base onto
DNA. As for the distribution of 5mCs, it is well known that they distribute themselves in a non …

[HTML][HTML] Theranostic biomarkers and PARP-inhibitors effectiveness in patients with non-BRCA associated homologous recombination deficient tumors: Still looking …

L Incorvaia, A Perez, C Marchetti, C Brando… - Cancer Treatment …, 2023 - Elsevier
Breast cancer susceptibility gene 1 (BRCA1) and breast cancer susceptibility gene 2
(BRCA2) deleterious variants were the first and, still today, the main biomarkers of poly …

Minireview exploring the biological cycle of vitamin B3 and its influence on oxidative stress: further molecular and clinical aspects

B Doroftei, OD Ilie, RO Cojocariu, A Ciobica, R Maftei… - Molecules, 2020 - mdpi.com
Vitamin B3, or niacin, is one of the most important compounds of the B-vitamin complex.
Recent reports have demonstrated the involvement of vitamin B3 in a number of pivotal …