Proliferation is an important part of cancer development and progression. This is manifest by
altered expression and/or activity of cell cycle related proteins. Constitutive activation of …

Non-alcoholic fatty liver disease (NAFLD) can manifest as non-alcoholic fatty liver (NAFL) or
non-alcoholic steatohepatitis (NASH). NASH is often associated with progressive fibrosis …

NAFLD affects a large proportion of the US population and its incidence and prevalence are
increasing to epidemic proportions around the world. As with other liver diseases that cause …

Although cancer immunotherapy based on immune checkpoint inhibitors holds great
promise toward many types of cancers, several challenges still remain, associated with low …

Primary liver cancer (PLC) is the fourth most frequent cause of cancer-related death. The
high mortality rates arise from late diagnosis and the limited accuracy of diagnostic and …

DNA methylation is an epigenetic mechanism that is essential for regulating gene
transcription. However, aberrant DNA methylation, which is a nearly universal finding in …

Nonalcoholic fatty liver disease (NAFLD) is a condition in which excess fat accumulates in
the liver of a patient without a history of alcohol abuse. Nonalcoholic steatohepatitis (NASH) …

A rapidly increasing incidence of non-alcoholic fatty liver disease (NAFLD) is noted
worldwide due to the adoption of western-type lifestyles and eating habits. This makes the …

Background & Aims Nonalcoholic fatty liver disease (NAFLD) is a consequence of defects in
diverse metabolic pathways that involve hepatic accumulation of triglycerides. Features of …

S-adenosylmethionine (AdoMet, also known as SAM and SAMe) is the principal biological
methyl donor synthesized in all mammalian cells but most abundantly in the liver …