Neonatal seizures: advances in mechanisms and management

HC Glass - Clinics in perinatology, 2014 - perinatology.theclinics.com
Neonates are at especially high risk for seizures as compared to other age groups. 1 The
high risk for seizures—and especially acute symptomatic seizures—is likely multifactorial …

[HTML][HTML] Consensus protocol for EEG and amplitude-integrated EEG assessment and monitoring in neonates

R Dilena, F Raviglione, G Cantalupo, DM Cordelli… - Clinical …, 2021 - Elsevier
The aim of this work is to establish inclusive guidelines on electroencephalography (EEG)
applicable to all neonatal intensive care units (NICUs). Guidelines on ideal EEG monitoring …

A universal system for digitization and automatic execution of the chemical synthesis literature

SHM Mehr, M Craven, AI Leonov, G Keenan, L Cronin - Science, 2020 - science.org
Robotic systems for chemical synthesis are growing in popularity but can be difficult to run
and maintain because of the lack of a standard operating system or capacity for direct …

A machine-learning algorithm for neonatal seizure recognition: a multicentre, randomised, controlled trial

AM Pavel, JM Rennie, LS de Vries… - The Lancet Child & …, 2020 - thelancet.com
Background Despite the availability of continuous conventional electroencephalography
(cEEG), accurate diagnosis of neonatal seizures is challenging in clinical practice …

Neonatal seizures—are we there yet?

G Ramantani, B Schmitt, B Plecko, RM Pressler… - …, 2019 - thieme-connect.com
Neonatal seizures are the most prevalent and distinctive sign of neurologic dysfunction in
early life and pose an immense challenge for clinicians. Improvements in neonatal care …

[HTML][HTML] Amplitude-integrated EEG for detection of neonatal seizures: a systematic review

A Rakshasbhuvankar, S Paul, L Nagarajan, S Ghosh… - Seizure, 2015 - Elsevier
Purpose Amplitude-integrated electroencephalogram (aEEG) is being used increasingly for
monitoring seizures in neonatal units. Its accuracy, compared with “the gold-standard” …

Pharmacotherapy for neonatal seizures: current knowledge and future perspectives

MD Donovan, BT Griffin, L Kharoshankaya, JF Cryan… - Drugs, 2016 - Springer
Seizures are the most common neurological emergencies in the neonatal period and are
associated with poor neurodevelopmental outcomes. Seizures affect up to five per 1000 …

Recommendations for the design of therapeutic trials for neonatal seizures

JS Soul, R Pressler, M Allen, G Boylan, H Rabe… - Pediatric …, 2019 - nature.com
Although seizures have a higher incidence in neonates than any other age group and are
associated with significant mortality and neurodevelopmental disability, treatment is largely …

Why we urgently need improved seizure and epilepsy therapies for children and neonates

RM Pressler, L Lagae - Neuropharmacology, 2020 - Elsevier
In contrast to epilepsy in adolescents and adults, neonatal seizures and early onset epilepsy
poses unique challenges with significant repercussion for treatment choices. Most …

Neonatal seizures in hypoxic–ischaemic encephalopathy–risks and benefits of anticonvulsant therapy

J Shetty - Developmental Medicine & Child Neurology, 2015 - Wiley Online Library
The risk of seizures is at its highest during the neonatal period, and the most common cause
of neonatal seizures is hypoxic–ischaemic encephalopathy (HIE). This enhanced …