The DNA methyltransferase family: a versatile toolkit for epigenetic regulation
F Lyko - Nature Reviews Genetics, 2018 - nature.com
The DNA methyltransferase (DNMT) family comprises a conserved set of DNA-modifying
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
enzymes that have a central role in epigenetic gene regulation. Recent studies have shown …
Activity-regulated transcription: bridging the gap between neural activity and behavior
EL Yap, ME Greenberg - Neuron, 2018 - cell.com
Gene transcription is the process by which the genetic codes of organisms are read and
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
interpreted as a set of instructions for cells to divide, differentiate, migrate, and mature. As …
MOFA+: a statistical framework for comprehensive integration of multi-modal single-cell data
Technological advances have enabled the profiling of multiple molecular layers at single-
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …
cell resolution, assaying cells from multiple samples or conditions. Consequently, there is a …
Dynamic DNA methylation: In the right place at the right time
The classical model of cytosine DNA methylation (the presence of 5-methylcytosine, 5mC)
regulation depicts this covalent modification as a stable repressive regulator of promoter …
regulation depicts this covalent modification as a stable repressive regulator of promoter …
[HTML][HTML] DNA methylation in human diseases
Z Jin, Y Liu - Genes & diseases, 2018 - Elsevier
Even though the importance of epigenetics was first recognized in light of its role in tissue
development, an increasing amount of evidence has shown that it also plays an important …
development, an increasing amount of evidence has shown that it also plays an important …
Single-cell DNA methylome and 3D multi-omic atlas of the adult mouse brain
Cytosine DNA methylation is essential in brain development and is implicated in various
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
neurological disorders. Understanding DNA methylation diversity across the entire brain in a …
CpG and non-CpG methylation in epigenetic gene regulation and brain function
HS Jang, WJ Shin, JE Lee, JT Do - Genes, 2017 - mdpi.com
DNA methylation is a major epigenetic mark with important roles in genetic regulation.
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …
Methylated cytosines are found primarily at CpG dinucleotides, but are also found at non …
DNA methylation atlas of the mouse brain at single-cell resolution
Mammalian brain cells show remarkable diversity in gene expression, anatomy and
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
function, yet the regulatory DNA landscape underlying this extensive heterogeneity is poorly …
[HTML][HTML] Cerebral organoids recapitulate epigenomic signatures of the human fetal brain
Organoids derived from human pluripotent stem cells recapitulate the early three-
dimensional organization of the human brain, but whether they establish the epigenomic …
dimensional organization of the human brain, but whether they establish the epigenomic …
Epigenetic mechanisms in neurogenesis
In the embryonic and adult brain, neural stem cells proliferate and give rise to neurons and
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …
glia through highly regulated processes. Epigenetic mechanisms—including DNA and …