DNA hypermethylation in disease: mechanisms and clinical relevance
M Ehrlich - Epigenetics, 2019 - Taylor & Francis
Increasing numbers of studies implicate abnormal DNA methylation in cancer and many non-
malignant diseases. This is consistent with numerous findings about differentiation …
malignant diseases. This is consistent with numerous findings about differentiation …
Understanding the physical basis of memory: Molecular mechanisms of the engram
C Ortega-de San Luis, TJ Ryan - Journal of Biological Chemistry, 2022 - ASBMB
Memory, defined as the storage and use of learned information in the brain, is necessary to
modulate behavior and critical for animals to adapt to their environments and survive …
modulate behavior and critical for animals to adapt to their environments and survive …
How the epigenome integrates information and reshapes the synapse
RR Campbell, MA Wood - Nature Reviews Neuroscience, 2019 - nature.com
In the past few decades, the field of neuroepigenetics has investigated how the brain
encodes information to form long-lasting memories that lead to stable changes in behaviour …
encodes information to form long-lasting memories that lead to stable changes in behaviour …
Role of epigenetic mechanisms in chronic pain
D Mauceri - Cells, 2022 - mdpi.com
Pain is an unpleasant but essential-to-life sensation, usually resulting from tissue damage.
When pain persists long after the injury has resolved, it becomes pathological. The precise …
When pain persists long after the injury has resolved, it becomes pathological. The precise …
Neuronal ensemble-specific DNA methylation strengthens engram stability
Memories are encoded by memory traces or engrams, represented within subsets of
neurons that are synchronously activated during learning. However, the molecular …
neurons that are synchronously activated during learning. However, the molecular …
Role of protein synthesis and DNA methylation in the consolidation and maintenance of long-term memory in Aplysia
K Pearce, D Cai, AC Roberts, DL Glanzman - Elife, 2017 - elifesciences.org
Previously, we reported that long-term memory (LTM) in Aplysia can be reinstated by
truncated (partial) training following its disruption by reconsolidation blockade and inhibition …
truncated (partial) training following its disruption by reconsolidation blockade and inhibition …
DNA methylation and establishing memory
C Bernstein - Epigenetics Insights, 2022 - journals.sagepub.com
A single event can cause a life-long memory. Memories physically reside in neurons, and
changes in neuronal gene expression are considered to be central to memory. Early models …
changes in neuronal gene expression are considered to be central to memory. Early models …
Epigenetic mechanisms of learning and memory: implications for aging
The neuronal epigenome is highly sensitive to external events and its function is vital for
producing stable behavioral outcomes, such as the formation of long-lasting memories. The …
producing stable behavioral outcomes, such as the formation of long-lasting memories. The …
The role of activity-dependent DNA demethylation in the adult brain and in neurological disorders
G Bayraktar, MR Kreutz - Frontiers in molecular neuroscience, 2018 - frontiersin.org
Over the last decade, an increasing number of reports underscored the importance of
epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and …
epigenetic regulations in brain plasticity. Epigenetic elements such as readers, writers and …
[HTML][HTML] Sex differences in neurodevelopmental abnormalities caused by early-life anaesthesia exposure: a narrative review
OH Cabrera, T Gulvezan, B Symmes… - British journal of …, 2020 - Elsevier
Exposure to anaesthetic drugs during the fetal or neonatal period induces widespread
neuronal apoptosis in the brains of rodents and non-human primates. Hundreds of …
neuronal apoptosis in the brains of rodents and non-human primates. Hundreds of …