Clinical and therapeutic relevance of cancer-associated fibroblasts
Cancer-associated fibroblasts (CAFs) found in primary and metastatic tumours are highly
versatile, plastic and resilient cells that are actively involved in cancer progression through …
versatile, plastic and resilient cells that are actively involved in cancer progression through …
Chemical and biomolecular strategies for STING pathway activation in cancer immunotherapy
KM Garland, TL Sheehy, JT Wilson - Chemical reviews, 2022 - ACS Publications
The stimulator of interferon genes (STING) cellular signaling pathway is a promising target
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
for cancer immunotherapy. Activation of the intracellular STING protein triggers the …
A molecular single-cell lung atlas of lethal COVID-19
Respiratory failure is the leading cause of death in patients with severe SARS-CoV-2
infection,, but the host response at the lung tissue level is poorly understood. Here we …
infection,, but the host response at the lung tissue level is poorly understood. Here we …
Multiplexed imaging mass cytometry of the chemokine milieus in melanoma characterizes features of the response to immunotherapy
Intratumoral immune cells are crucial for tumor control and antitumor responses during
immunotherapy. Immune cell trafficking into tumors is mediated by binding of specific …
immunotherapy. Immune cell trafficking into tumors is mediated by binding of specific …
[HTML][HTML] Fungal mycobiome drives IL-33 secretion and type 2 immunity in pancreatic cancer
A Alam, E Levanduski, P Denz, HS Villavicencio… - Cancer cell, 2022 - cell.com
TH 2 cells and innate lymphoid cells 2 (ILC2) can stimulate tumor growth by secreting pro-
tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the …
tumorigenic cytokines such as interleukin-4 (IL-4), IL-5, and IL-13. However, the …
The therapeutic age of the neonatal Fc receptor
IgGs are essential soluble components of the adaptive immune response that evolved to
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …
protect the body from infection. Compared with other immunoglobulins, the role of IgGs is …
GTP cyclohydrolase 1/tetrahydrobiopterin counteract ferroptosis through lipid remodeling
VAN Kraft, CT Bezjian, S Pfeiffer… - ACS central …, 2019 - ACS Publications
Ferroptosis is an iron-dependent form of regulated cell death linking iron, lipid, and
glutathione levels to degenerative processes and tumor suppression. By performing a …
glutathione levels to degenerative processes and tumor suppression. By performing a …
Innovations in genomics and big data analytics for personalized medicine and health care: A review
Big data in health care is a fast-growing field and a new paradigm that is transforming case-
based studies to large-scale, data-driven research. As big data is dependent on the …
based studies to large-scale, data-driven research. As big data is dependent on the …
The allergy mediator histamine confers resistance to immunotherapy in cancer patients via activation of the macrophage histamine receptor H1
H Li, Y Xiao, Q Li, J Yao, X Yuan, Y Zhang, X Yin… - Cancer cell, 2022 - cell.com
Reinvigoration of antitumor immunity remains an unmet challenge. Our retrospective
analyses revealed that cancer patients who took antihistamines during immunotherapy …
analyses revealed that cancer patients who took antihistamines during immunotherapy …
GEPIA2: an enhanced web server for large-scale expression profiling and interactive analysis
Introduced in 2017, the GEPIA (Gene Expression Profiling Interactive Analysis) web server
has been a valuable and highly cited resource for gene expression analysis based on tumor …
has been a valuable and highly cited resource for gene expression analysis based on tumor …