From an adaptation perspective, unoccupied patches of morphological space are inferred to
be empty because they are of low fitness and selected against. These inferences hinge on …

When used during pregnancy, analgesics and psychotropics pass the placenta to enter the
foetal circulation and may induce epigenetic modifications. Where such modifications occur …

Pluripotent stem cells recapitulate many aspects of embryogenesis in vitro. Here, we
established a novel culture system to differentiate human embryonic stem cell aggregates …

Background Remdesivir is an antiviral drug approved for the treatment of COVID‐19, whose
developmental toxicity remains unclear. More information about the safety of remdesivir is …

Molnupiravir is a nucleoside analog antiviral that is authorized for use in the treatment of
COVID-19. For its therapeutic action, molnupiravir is converted after ingestion to the active …

Dolutegravir (DTG) is an antiretroviral drug of the integrase strand transfer inhibitor (INSTI)
class used to treat human immunodeficiency virus infection. It is the recommended first-line …

This manuscript provides a review focused on embryonic stem cell-based models and their
place within the landscape of alternative developmental toxicity assays. Against the …

Low oxygen concentration (hypoxia) is part of normal embryonic development, yet the
situation is complex. Oxygen (O2) is a janus gas with low levels signaling through hypoxia …

Impact ionization of high-velocity cosmic dust particles has been used as a basic principle
for dust detectors in space for many decades. It has provided optimum means to gain insight …

There is evidence that the susceptibility to the teratogenic effect of drugs within human
populations varies extremely from one individual to another, even after identical exposures …