Growing evidence implicates the brain in the regulation of both immediate fuel availability
(for example, circulating glucose) and long-term energy stores (that is, adipose tissue mass) …

It has been thought that caloric restriction favors longevity and healthy aging where
autophagy plays a vital role. However, autophagy decreases during aging and that can lead …

Recent genome-wide association studies corroborate classical research on developmental
programming indicating that obesity is primarily a neurodevelopmental disease strongly …

The perinatal period presents a critical time in offspring development where environmental
insults can have damaging impacts on the future health of the offspring. This can lead to …

Alterations in the nutritional environment in early life can significantly increase the risk for
obesity and a range of development of metabolic disorders in offspring in later life, effects …

Maternal overnutrition during lactation predisposes offspring to develop metabolic diseases
and exacerbates the relevant syndromes in males more than females in later life. The …

Lipopolysaccharide (LPS) tolerance can reduce the neuroinflammation caused by high fat
maternal diets; however, there are no reports that have evaluated the effects of prenatal LPS …

In the arcuate nucleus of the hypothalamus reside two neuronal systems in charge of
regulating feeding control and reproductive development. The melanocortin system …

Developmental exposure to toxicants and diet can interact with an individual's genetics and
produce long-lasting metabolic adaptations. The different isoforms of the apolipoprotein E …

While environmental epigenetics mainly focuses on xenobiotic endocrine disruptors, dietary
composition might be one of the most important environmental exposures for epigenetic …